Project Grant R01CA287731

Award Date 9/13/24
Completion Date 8/31/29
Dollars Obligated $571K
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
Buffalo, NY 14263, USA
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This federal Project Grant award of $107,948.00 from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) supports research to investigate the role of the MALT1 protein in promoting immunosuppression in triple-negative breast cancer (TNBC). The award recipient, the University of Pittsburgh, will conduct a two-part research project. In Aim 1, the team will analyze how MALT1 protease activity within TNBC cells regulates the tumor immune microenvironment...
This Project Grant award from the National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), supports a two-pronged approach to target triple-negative breast cancer (TNBC). The $403,686 award, effective June 1, 2024 through May 31, 2026, will enable researchers at Rutgers, The State University of New Jersey to: Explore the use of a targeted hybrid vector called AAVP to deliver human tumor necrosis factor (TNF) to both TNBC tumor cells and associated...
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This $460,977 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) supports research to identify novel "chemo-neoepitopes" (CNEs) that can be used as immunogens to mobilize tumor-specific CD8+ T cells for immunotherapy against triple-negative breast cancer (TNBC). The research, conducted by Health Research, Inc. at the Roswell Park Division, aims to: 1) identify candidate CNE peptide sequences generated by...
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This Project Grant award of $571,496 from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) will support research to understand the role of the tumor protein TAZ in regulating the immune environment in triple-negative breast cancer (TNBC). The award, which runs from September 2024 to August 2029, will allow researchers at the University of Toledo Health Science Campus Division to:

  1. Determine how tumor-specific TAZ expression impacts the immune landscape of the TNBC tumor microenvironment in preclinical models.
  2. Elucidate the molecular mechanisms by which TAZ expression in TNBC cells recruits immunosuppressive myeloid-derived suppressor cells.
  3. Investigate the relationship between TAZ expression in TNBC tumors and the immune profile of the tumor microenvironment in patient samples.

The goal of this research is to uncover new biomarkers and therapeutic targets related to the TAZ-mediated regulation of the immune response in TNBC, which is an aggressive subtype with limited treatment options. The University of Toledo is a well-established recipient of NIH cancer research grants and has extensive expertise in conducting federal grant-funded preclinical and translational studies across various cancer biology focus areas.

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