Project Grant R01CA292532

Award Date 5/1/25
Completion Date 4/30/30
Dollars Obligated $540K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Florida, USA
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This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides funding of $684,367 to support research aimed at identifying intratumoral microbiome profiles and spatial immune signatures that can predict response to immune checkpoint inhibitor therapy in patients with non-small cell lung cancer. The project, led by researchers at Baylor College of Medicine, will analyze pre-treatment tumor samples from three independent cohorts (totaling...
This federal Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides $636,222 to the University of Pittsburgh to conduct research on how immune checkpoint inhibitor-associated bacteria can modulate tumor immunity in cancer, with a focus on melanoma. The overarching goal is to understand the mechanisms by which certain gut bacteria can produce aryl hydrocarbon receptor (AhR) ligands that enhance anti-tumor CD8+ T cell (TC1) immunity, thereby...
This Project Grant award from the National Cancer Institute (NCI), under the Cancer Treatment Research federal grant program (CFDA 93.395), will support research at the University of Chicago to investigate the use of genetically-engineered Bifidobacterium bacteria for enhancing tumor control in combination with radiotherapy and/or immunotherapy for metastatic pancreatic ductal adenocarcinoma (PDAC). The $581,087 award, with a period of performance from July 1, 2024 to June 30, 2029, will focus...
This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) supports research to modulate the human microbiome to enhance immune responses against cancer. The $179,988 award to The Leland Stanford Junior University, a private research university, aims to identify bacterial functions that can improve response to immune checkpoint blockade cancer therapies. Key objectives include: Aggregating and analyzing metagenomic data to identify microbial genes...
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This federal Project Grant award of $540,288 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) will fund research at the University of Florida to characterize a bacterial-derived metabolite called BAC429 and its mechanism of action in improving the anti-tumor efficacy of anti-PD-1 immunotherapy treatment for non-small cell lung cancer.

The central hypothesis is that specific bacteria produce small molecules like BAC429 that can modulate immune responses and enhance the effectiveness of cancer immunotherapies. The proposed research aims to: 1) define the functional impact of BAC429 on experimental non-small cell lung cancer, 2) establish the relationship between diet and BAC429 production in enhancing anti-PD-1 treatment, and 3) design structural modifications to BAC429 to improve its solubility, bioavailability, and anti-tumor immune effects. This 5-year project starting on May 1, 2025 seeks to advance the understanding of how microbial-derived metabolites can be leveraged to augment cancer immunotherapy responsiveness.

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