This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $509,246 to the Regents of the University of Michigan to conduct research aimed at understanding the early drivers of prostate cancer lineage plasticity. The research project, titled "Targeting Early Drivers of Prostate Cancer Lineage Plasticity", seeks to identify key transcriptional regulators that initiate the loss of androgen receptor signaling and promote alternative differentiation programs in prostate cancer, a critical determinant of treatment resistance and lethality. The 5-year project, running from April 2025 to March 2030, will investigate the mechanisms by which these transcriptional regulators modulate differentiation state and cancer hallmarks, determine how they are upregulated in human tumors, and evaluate the effects of targeting them in vivo. The goal is to develop new strategies to block this critical network and improve outcomes for patients across the lineage plasticity continuum.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $509.2k | 4/9/25 |