The Research Foundation For The State University Of New York, doing business as Stony Brook University, received a $355,625 Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) to investigate the role of luminal intermediate cells and their WNT-p63 signaling in prostate cancer development and progression. The 5-year research project, awarded on May 28, 2024, aims to elucidate the cellular and molecular mechanisms underlying luminal plasticity in prostate tumorigenesis, with the goal of identifying new targetable pathways to halt cancer progression. The study will employ functional analyses, loss- and gain-of-function approaches, and gene regulatory network analyses to understand how the luminal intermediate cell state and associated signaling contribute to clonal expansions in normal aging and malignant prostate conditions.
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