Project Grant R01CA288612

Award Date 1/1/25
Completion Date 12/31/29
Dollars Obligated $696K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Charlottesville, VA, USA
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This federal Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides $696,447.00 to support research focused on developing novel imaging and targeted alpha particle therapy approaches for malignant mesothelioma. The award supports the University of Virginia as the prime recipient in:

  1. Evaluating a 203Pb-labeled antibody targeting the CD46 tumor antigen for SPECT imaging to detect mesothelioma across subtypes, including the hard-to-treat sarcomatoid subtype.

  2. Developing a 212Pb-labeled version of the same antibody for targeted alpha particle therapy and assessing its efficacy and tolerability in mesothelioma cell line and patient-derived xenograft models.

The award includes sub-grants to the University of California, San Francisco for antibody engineering, characterization, and target analysis, as well as the University of Alabama at Birmingham for providing expertise on radionuclide pharmacokinetics and dosimetry calculations. The project aims to translate these targeted imaging and therapy approaches into future clinical trials for mesothelioma patients.

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