Project Grant R44CA291419

Award Date 2/1/25
Completion Date 1/31/27
Dollars Obligated $1M
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Maryland, USA
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The federal Project Grant award R44CA291419 was provided by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) to Radiopharmaceutical Imaging And Dosimetry, LLC, a for-profit limited liability company based in Baltimore, Maryland. The $1,003,173 award, with a project period from February 1, 2025 to January 31, 2027, aims to develop a prototype web/cloud-based quantitative SPECT reconstruction software system for clinical trials and dosimetry of radiopharmaceutical therapy (RPT) using alpha-emitting radionuclides. The key products/services to be delivered include: (1) improving quantitative methods for SPECT imaging of RPT radionuclides by enhancing scatter/downscatter modeling and partial volume compensation; (2) optimizing energy windows and collimators for quantitative imaging; (3) developing practical calibration methods; and (4) validating and characterizing the quantitative SPECT methods. This work will provide a well-characterized, validated platform for quantitative SPECT of alpha-emitter RPT radionuclides that can be used in clinical trials and serve as the basis for a commercial dosimetry product.

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