This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $417,858 to Brigham & Women's Hospital Inc. to develop a novel cellular therapy platform for the treatment of glioblastoma, a highly malignant brain cancer. The project aims to engineer mesenchymal stem cells (MSCs) to release bi-specific T-cell engager (BiTE) molecules targeting multiple tumor antigens (EGFR, EGFRvIII, IL13RA2) and co-express IL-12 and immune checkpoint inhibitors. These engineered MSCs will be encapsulated in a synthetic extracellular matrix and assessed for their ability to recruit and activate T cells to eliminate glioblastoma cells in preclinical mouse models. The award period is from January 2025 to December 2029 and builds on the awardee's previous research demonstrating the therapeutic potential of engineered MSCs for glioblastoma.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $417.9k | 1/7/25 |