Project Grant R01CA294071

Award Date 9/19/24
Completion Date 8/31/29
Dollars Obligated $653K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Boston, MA 02114, USA
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The funded project aims to test the safety and feasibility of injecting CAR T-cells engineered to secrete a T-cell engaging antibody (CARV3.TEAM-E cells) directly into the cerebrospinal fluid of glioblastoma patients. The CARV3.TEAM-E cells are designed to target the epidermal growth factor receptor (EGFR) and its mutant form EGFRVIII, which are expressed in glioblastoma. The goal is for the TEAM antibody to activate other T-cells in the tumor microenvironment, including converting suppressive regulatory T-cells into killer cells, to enhance the CAR T-cell therapy's anti-tumor effects. This Phase I clinical trial will monitor safety, measure CAR T-cell persistence and tumor infiltration, and analyze changes in tumor antigen expression and immune cell composition. The project runs from September 2024 through August 2029.

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