Project Grant R01CA285856

Award Date 7/2/24
Completion Date 6/30/29
Dollars Obligated $583K
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
New York, NY 10065, USA
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This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $583,127 to the Sloan-Kettering Institute for Cancer Research to investigate the mechanisms by which deficiency of the SMARCA4 gene promotes metastasis in lung adenocarcinoma. The key activities include:

  1. Performing multi-omics analyses (RNA-seq, ChIP-seq, ATAC-seq, mass spectrometry) to elucidate how SMARCA4 deficiency regulates transcription and promotes metastasis in lung cancer cells. This includes an in vivo CRISPR/sgRNA screen to identify functional downstream transcription factors.

  2. Evaluating the therapeutic potential of targeting the ROR2/p-GSK3Bβ pathway to suppress metastasis in SMARCA4-deficient lung adenocarcinoma. This will involve assessing the clinical relevance in patient samples, testing in a patient-derived organoid model, and investigating the pathway in a genetically engineered mouse model.

The award period runs from July 2, 2024 to June 30, 2029 and aims to provide mechanistic and translational evidence to support future clinical trials targeting ROR2 in SMARCA4-deficient lung cancer to reduce metastasis.

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