This $946,540 project grant from the National Cancer Institute, part of the Department of Health and Human Services, supports research under the Cancer Treatment Research program. Health Research-Roswell Park Cancer Institute Division will target HNF1A-mediated therapeutic resistance in pancreatic ductal adenocarcinoma. The researchers will characterize regulation of the HNF1A gene by the BRD4 protein and establish bromodomain inhibitors as a means to overcome HNF1A-mediated resistance to KRAS pathway suppression. Specifically, they will examine HNF1A's role in BRD4-mediated cell growth and survival, and how HNF1A determines response to bromodomain inhibitors. They will also study how HNF1A promotes resistance to targeting the KRAS signaling pathway. This research seeks to improve understanding of pancreatic cancer biology and identify novel therapeutic targets, with the goal of developing more effective treatment strategies, including for pancreatic cancer stem cells. The grant period is from February 3, 2023 through December 31, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $473.3k | 2/3/23 | ||
| Not listed | $473.3k | 2/3/23 |