Project Grant R01AT013417
- The National Center for Complementary and Integrative Health (NCCIH), a component of the Department of Health and Human Services National Institutes of Health, awarded $407,856 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University on August 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The recipient will conduct research examining how alpha-frequency transcranial alternating current stimulation (tACS) targeting...
- The National Institutes of Health National Center for Complementary and Integrative Health awarded $1,322,441 to the University of California, San Diego on August 11, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to conduct a multi-site feasibility study in preparation for a definitive clinical trial randomizing patients with acute pain to battlefield acupuncture, battlefield acupressure, or sham treatment. Acute postoperative pain affects...
- The National Center for Complementary and Integrative Health (NCCIH) awarded the University of Massachusetts Medical School a $297,373 cooperative agreement on August 17, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds a Data Coordinating Center (U24) to provide statistical and data management leadership for a multi-center Phase 3 randomized controlled trial (ACUITY 2) examining whether acupuncture is superior to usual care for...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded Case Western Reserve University $189,000 on July 20, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). Case Western Reserve University, through its Office of Research Administration in affiliation with University Hospitals of Cleveland, will conduct a randomized, sham-controlled, parallel-group feasibility trial...
- The National Center for Complementary and Integrative Health awarded University of California Irvine a cooperative agreement for $1,214,743 on August 15, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds planning and pilot activities for ACUITY 2, a multi-center Phase 3 randomized controlled trial of acupuncture versus usual care for acute pain management in emergency departments. The planning phase includes three aims:...
- The National Institute of Neurological Disorders and Stroke awarded the Regents of the University of Michigan a $6.827 million cooperative agreement on September 19, 2025, to conduct a Sequential Multiple Assignment Randomized Trial (SMART) evaluating personalized treatment algorithms for chronic low back pain across pharmacological, physical therapy, cognitive-behavioral, and mobile health self-management interventions. The University of Michigan's Back Pain Consortium Mechanistic Research...
- The National Center for Complementary and Integrative Health (NCCIH) at the National Institutes of Health awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $170,640 on April 17, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The award funds development and feasibility testing of TOPMED (Toolkit for Optimal Pain Management in the Emergency Department), a mind-body intervention designed to reduce pain...
- The National Center for Complementary and Integrative Health awarded Regents of the University of Michigan $574,978 on August 7, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to conduct a multi-site feasibility study of CAN-COACH, a cannabis coaching intervention for chronic low back pain. CAN-COACH uses motivational interviewing to coach individuals on the use of commercially available cannabis products for pain management, focusing on...
- The National Center for Complementary and Integrative Health of the National Institutes of Health awarded the University of Rochester $550,030 on April 9, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to investigate the biological mechanisms linking circadian regulation of cerebrospinal fluid movement through the glymphatic and lymphatic systems to chronic neuropathic pain development. The research spans three aims: testing whether...
- The National Institute of Neurological Disorders and Stroke awarded Case Western Reserve University $3,778,614 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate transient selective neural inhibition via photobiomodulation (TSNIP) for chronic knee pain treatment. The research integrates optimized TSNIP parameters into the COSMIIC modular platform—an FDA-qualified system already proven safe for electrical stimulation and sensing in...
The National Center for Complementary and Integrative Health, part of the National Institutes of Health within the Department of Health and Human Services, awarded $1,671,750 to the Regents of the University of Michigan on August 11, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to conduct a pilot trial of transcutaneous electrical accustimulation (TEA) for chronic pain management in patients with cirrhosis. The recipient will conduct the COMFORT Pilot Trial, an eight-week sham-controlled trial of patch-based TEA among patients with cirrhosis and chronic pain. The TEA method uses surface electrodes rather than needles to deliver electrical stimulation, enabling remote, at-home therapy. The research builds on prior studies showing that the recipient's novel TEA approach with specialized stimulation parameters and location-specific treatment regimens improves autonomic function and inflammation while reducing central pain augmentation. Chronic pain affects 40 to 79 percent of people with cirrhosis, a disease affecting more than two million Americans. Conventional pain management approaches for cirrhosis are unsafe and ineffective, particularly for nociplastic pain. The trial addresses a gap in research on integrative therapy for this population. Work is performed in Ann Arbor, Michigan, with period of performance through July 31, 2029. The award is a Project Grant, assistance type R01.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.7m | 8/13/26 |