Project Grant R01AR087805
- Federal Grant Award Summary Weill Medical College of Cornell University received a $216,113 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective June 1, 2025, through May 31, 2027. The research project investigates therapeutic targeting of GDF15-GFRAL (growth differentiation factor 15-GFRAL receptor) signaling to treat mitochondrial myopathy, a...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Rochester a $547,767 project grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) effective June 1, 2026, through May 31, 2031. This research initiative focuses on identifying host mechanisms governing Staphylococcus aureus persistence during implant-associated osteomyelitis, a significant clinical challenge in...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Regents of the University of California, San Francisco a $219,609 Project Grant on September 5, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop an innovative in vitro methodology for detecting changes in bone matrix mechanical properties. The primary deliverable is the establishment and validation of a micropillar-based...
- Federal Grant Award Summary The University of Pennsylvania received a $646,506 Project Grant award dated September 5, 2025, from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This grant supports the development of dual-action nanoparticle-loaded microparticles designed to treat osteoarthritis (OA) through a novel combination therapeutic approach. The research delivers...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The University of Pennsylvania a $507,606 Project Grant (CFDA 93.846: Arthritis, Musculoskeletal and Skin Diseases Research) effective June 1, 2026, through March 31, 2031. This award funds research investigating the mechanotransductive mechanisms by which mechanical loading influences tendon cell behavior through focal adhesion kinase (FAK) signaling. The project deliverables...
- Federal Project Grant Award Summary The Hospital For Special Surgery Fund, Inc. (HSS Foundation) received a $445,217 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 1, 2025, through August 31, 2030. This five-year research initiative focuses on elucidating the regulatory mechanisms of osteoclasts, the multinucleated cells...
- Federal Project Grant Award Summary Cornell University's Office of Sponsored Programs received a $420,000 Project Grant from the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering program (CFDA 47.041), awarded June 1, 2025, with completion targeted for May 31, 2028. This collaborative research initiative delivers fundamental scientific research and theoretical modeling capabilities focused on understanding how articular...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $372,171 Project Grant to The Research Foundation for the State University of New York (RF SUNY), effective June 1, 2026, through May 31, 2028, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds research into the mechanistic investigation of galectin-3 (GAL3)-expressing macrophages in fracture callus fibrosis and...
- Federal Grant Award Summary Cornell University received a $125,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026 through April 30, 2028. The award supports fundamental research to decode inter-organelle phospholipid transport through innovative fluxome profiling methodology. The research will establish a comprehensive method to measure phospholipid transport in...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded New Jersey Institute of Technology a $330,107 Project Grant effective September 1, 2025, through June 30, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award supports fundamental research investigating the role of stress anisotropy—directional stress differences in extracellular matrices—in fibroblast activation and its...
Cornell University received a $390,956 Project Grant award dated May 28, 2026, from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research on targeted modulation of osteocyte Wnt signaling using peptide-functionalized nanoparticles through April 30, 2031. The project addresses a significant gap in therapeutic development by creating a novel drug delivery platform capable of reaching osteocytes—the principal mechanosensors and regulators of bone remodeling—which have remained an untapped therapeutic target due to their deep embedding within the mineralized bone matrix and resistance to conventional drug delivery strategies. The research platform leverages ultrasmall nanoparticles to enable osteocyte-specific therapeutic modulation, with anticipated deliverables including preclinical research data, mechanistic insights into osteocyte Wnt signaling pathways, and prototype nanoparticle formulations that could advance treatment options for bone-related disorders. This award represents NIAMS's investment in innovative technology development within the musculoskeletal disease research portfolio and aligns with the program's emphasis on developing novel therapeutic interventions and diagnostic approaches for arthritis and musculoskeletal conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $391.0k | 6/1/26 |