Project Grant R01AR087398
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $2,058,020 Project Grant to Icahn School of Medicine at Mount Sinai, effective June 1, 2026 through May 31, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award funds the development and validation of an engineered messenger RNA (mRNA) therapeutic designed to address rotator cuff muscle degeneration. The research will...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Texas at Arlington a $711,976 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) effective May 15, 2026, with completion targeted for April 30, 2031. This research initiative addresses the critical clinical need for improved diagnostic imaging of orthopedic implant infections (OII) caused by both gram-positive and...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $151,040 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective April 15, 2026, with completion targeted for November 30, 2028. The project focuses on developing muscle-optimized non-viral gene editors to improve therapeutic outcomes for Duchenne Muscular...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a Project Grant award of $412,756.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective July 5, 2025, with a completion date of June 30, 2030. The award supports research into the mechanisms regulating bone healing and angiogenesis in osteonecrosis of the femoral head...
- Federal Project Grant Award Summary The University of Texas at San Antonio received a $221,252 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop an innovative drug delivery system for modulating adipose tissue function. The grant, awarded on September 12, 2025, with completion targeted for August 31, 2026, supports preclinical research...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Trustees of The University of Pennsylvania a $100,331 Project Grant (CFDA 93.846: Arthritis, Musculoskeletal and Skin Diseases Research) effective May 5, 2026, through April 30, 2028. This research project investigates the roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation. The research addresses the high non-response rate to...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $400,693 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded September 1, 2025, with a completion date of August 31, 2027. This research project investigates the role of PIEZO2-mediated mechanosensory signaling in pediatric clubfoot deformity repair, with a...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of California, San Diego a $675,131 Project Grant effective August 1, 2025, through June 30, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award funds research to develop ultrashort echo time (UTE) magnetic resonance imaging (MRI) techniques for early detection of knee osteoarthritis (OA). The project addresses...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded New Jersey Institute of Technology a $330,107 Project Grant effective September 1, 2025, through June 30, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award supports fundamental research investigating the role of stress anisotropy—directional stress differences in extracellular matrices—in fibroblast activation and its...
- Federal Project Grant Award Summary The University of Texas at Arlington received a $360,188 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2030. This award supports a five-year research initiative focused on developing and applying chemical proteomics strategies to quantify inflammatory protein networks and post-translational modifications...
The University of Texas at San Antonio received a $602,113 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective May 1, 2026 through April 30, 2031. The award supports research into browning of fatty infiltration in rotator cuff tears using novel nanotherapeutics. The research aims to address the challenge of fatty infiltration (FI) and muscle atrophy in the supraspinatus muscle following rotator cuff tears, conditions that are currently irreversible and significantly impair surgical repair outcomes and muscle regeneration. The project develops and evaluates a nanomedicine platform utilizing lipid-coated mesoporous silica nanoparticles loaded with forskolin to induce conversion of white adipose tissue to metabolically active beige adipose tissue. This approach seeks to promote local fat browning, enhance anti-inflammatory signaling, and improve myogenesis and muscle repair outcomes following rotator cuff injury. The research outputs will include preclinical and translational data on the efficacy of this novel nanotherapeutic intervention, with potential applications toward developing new therapeutic strategies for reversing fatty infiltration-related muscle degeneration in shoulder pathology.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $602.1k | 5/4/26 |