Project Grant R01AR085874
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Johns Hopkins University $543,417 on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate functional neuromuscular regeneration following chronic volumetric muscle loss in aged mice. The research addresses the restoration of neuromuscular junctions after volumetric muscle loss, a critical-sized skeletal muscle injury in which natural healing...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Duke University $124,875 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate muscle-to-bone communication during fracture repair and musculoskeletal regeneration. The research identifies pro-regenerative signals from injured muscle that orchestrate repair of both bone and muscle tissue. Preliminary findings...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Johns Hopkins University $671,214 on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate somatosensory nerve regulation of fracture repair. The research focuses on the role of tropomyosin receptor kinase A (TrkA)-positive sensory neurons in bone healing, specifically examining how these neurons regulate fracture repair through the release of...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Johns Hopkins University $569,402 on July 2, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate clinical heterogeneity in immune checkpoint inhibitor-induced inflammatory arthritis. The recipient will conduct prospective clinical studies leveraging the RADIOS (Rheumatology Adverse Events due to Immunotherapy Observational Study) cohort, a multicenter USA...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Johns Hopkins University $697,369 on August 5, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate nerve-tendon crosstalk as a mechanism for enhancing tendon repair while mitigating pain-related responses. The project focuses on separating regenerative signaling pathways from pain signaling pathways following tendon injury. Research will examine how nerve...
- Federal Cooperative Agreement Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Johns Hopkins University a Cooperative Agreement totaling $267,527 (awarded September 10, 2025, with completion by August 31, 2026) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds a clinical research study investigating optimal timing of flap coverage surgery in the treatment of severe lower extremity...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Biosensics LLC $314,362 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) on September 1, 2026, to develop digital assessment tools for motor skills in infants and young boys with Duchenne muscular dystrophy using wearable sensors. The project addresses a critical clinical gap: current motor assessment methods (Bayley Scales of Infant and Toddler Development) cannot detect...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Florida $1.768 million on September 15, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to assess magnetic resonance measures of bioenergetics and microvascular function in Duchenne and Becker muscular dystrophy. The project evaluates whether MR-based measures of muscle energetics and blood vessel function can track disease progression and treatment...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $117,426 to the University of California, San Diego on June 18, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop a noninvasive MRI method for assessing bone quality in type 2 diabetes patients. The project develops an ultrashort echo time quantitative magnetization transfer (UTE-QMT) MRI technique to measure collagen crosslinking in cortical bone, a bone quality...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Regents of the University of California, San Francisco $448,563 on September 5, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) for an ancillary study investigating systemic bone loss mechanisms following fracture. UCSF will conduct multimodal analysis of circulating cells and factors in blood samples collected from fracture patients at multiple timepoints...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Johns Hopkins University $187,172 on July 17, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to conduct a prospective, multi-center observational study validating biochemical and imaging biomarkers as predictors of incident fracture in Duchenne muscular dystrophy. The study will enroll 150 people with DMD over two years and operate across three leading neuromuscular programs: The Johns Hopkins University/Kennedy Krieger Institute (Baltimore, MD), The Children's Hospital of Philadelphia, and Cincinnati Children's Hospital Medical Center. The candidate biochemical biomarkers include circulating endothelial cells and serum platelet-derived growth factor type BB, both predictive of future fracture in preliminary data. Imaging assessments include bone density velocity from DXA scans, bone health index from hand X-rays, and trabecular bone score measuring lumbar spine bone microarchitecture. Accelerated fracture time models will be constructed for each biomarker to determine ability to predict fracture risk. The research addresses a clinical gap in DMD care: patients develop early-onset osteoporosis from neuromuscular weakness and chronic high-dose glucocorticoid exposure, with fragility fractures extremely common during childhood. Current standard practice waits until after the first fracture to initiate bone-strengthening pharmacotherapy. Identifying high-risk patients before fracture would enable primary prevention clinical trials. Period of performance runs through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $187.2k | 7/21/26 |