Project Grant R01AR085676
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop specialized cryo-electron microscopy (cryo-EM) techniques to study the structures of mitochondrial complexes implicated in muscular myopathies. The $444,109 award to the Scripps Research Institute in La Jolla, CA will support the creation of methods to directly visualize endogenous...
- This federal Project Grant award of $671,240 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to develop enhanced dystrophin gene therapies for Duchenne muscular dystrophy (DMD). The University of Washington will conduct this research from January 2025 through December 2029. The project aims to design and test micro-, mini-, and full-length dystrophin gene...
- This federal Project Grant award of $471,513 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to investigate the mechanisms underlying neuromuscular diseases where glycosylation is disrupted. The University of Maine System, through its Research & Sponsored Program division, will use a zebrafish model to study how loss of the dolichylphosphate mannose...
- This Project Grant award of $522,714 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of stretch activation in mammalian skeletal muscle endurance. The research will focus on measuring the characteristics and mechanisms of stretch activation in mouse slow-twitch and fast-twitch muscle fibers, including determining the specific myosin...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $198,263 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to the Board of Regents of the University of Nebraska. The research project aims to investigate the role of the protein Mitsugumin 53 (MG53) in preventing muscle atrophy during periods of disuse, which can contribute to age-related sarcopenia and frailty. The research will explore how...
- This Project Grant award of $719,758 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research on the role of nuclear myotubularin (MTM1) in muscle development and the pathogenesis of X-linked myotubular myopathy (XLMTM). The research aims to characterize the localization and interactome of nuclear MTM1, define alterations in nuclear structure and genome...
- This federal Project Grant award of $1,476,000.00 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) and is being performed by the University of Texas Southwestern Medical Center (UT Southwestern) in Dallas, TX. The award will fund research to investigate the role of membraneless cellular compartments, known as biomolecular condensates, in neuromuscular diseases and other age-related disorders. The project aims to develop new...
- The Project Grant award of $528,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to reveal the molecular basis of microtubule-intermediate filament interactions. The research will focus on understanding how microtubules and neurofilaments, which are key cytoskeletal components in myelinated axons, are adapted to form specialized cytoskeletal arrays that regulate cell shape and...
- This federal Project Grant award of $175,500 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of alternative splicing in Facioscapulohumeral Muscular Dystrophy (FSHD). The research project, performed by The Washington University, has three key objectives: 1) Characterize the interactions between the transcription factor DUX4 and RNA in...
- This Project Grant award, totaling $125,000.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will fund research at Emory University to investigate the role of protein N-myristoylation in driving the DNA damage response (DDR), which is crucial for maintaining genomic stability. The research aims to: 1) assess the association of N-myristoylation, modulated by the enzymes NMT1 and...
This Project Grant award of $352,750 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the mechanisms and regulation of the nuclear envelope protein emerin. The research aims to understand how emerin self-assembles and how this impacts nuclear mechanics, with implications for the genetic disorder Emery-Dreifuss muscular dystrophy. The project integrates quantitative proteomics, super-resolution microscopy, nuclear biomechanics, and single-molecule biophysical studies to examine the regulation of emerin self-assembly in muscle and non-muscle cells, as well as the molecular steps and conformational changes that allow emerin oligomerization to promote nuclear compliance against mechanical forces. This 5-year research effort, with an award date of August 10, 2025 and an ultimate completion date of July 31, 2030, will be conducted by the University of Southern California.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $352.8k | 7/29/25 |