Project Grant R01AR085652
- Federal Project Grant Award Summary The University of Pennsylvania received a $1,258,558 Project Grant awarded on September 5, 2025, by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports the development of a dual-action nanoparticle-loaded microparticle therapeutic platform designed to treat osteoarthritis (OA), a leading cause of disability in the United...
- Federal Grant Award Summary Northeastern University received a $652,195 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), with an award date of June 17, 2026 and completion date of May 31, 2031. The project delivers research and development services focused on engineering surface-modified exosomes derived from mesenchymal stem cells (MSC) as non-viral...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of California, San Diego a $675,131 Project Grant effective August 1, 2025, through June 30, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award funds research to develop ultrashort echo time (UTE) magnetic resonance imaging (MRI) techniques for early detection of knee osteoarthritis (OA). The project addresses...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded a $2.02 million Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Washington University, with performance extending from September 10, 2025 through August 31, 2028. This research initiative delivers a comprehensive investigation into the safety profile of intra-articular corticosteroid (IACS) injections—routine outpatient...
- Federal Project Grant Award Summary Flex Orthopaedics, Inc. received a $613,742 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 19, 2025, with completion anticipated by August 31, 2027. The award funds development and optimization of a compliant intramedullary tibial stem designed to extend the functional longevity of revision total...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Mayo Clinic a $668,801 Project Grant (CFDA 93.846 – Arthritis, Musculoskeletal and Skin Diseases Research) on July 7, 2025, with a completion date of May 31, 2030. The grant supports research focused on developing a non-surgical therapeutic intervention for arthrofibrosis, a debilitating joint condition affecting approximately 5% of total knee arthroplasty (TKA) patients. The...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $1.95 million Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 10, 2025, with an ultimate completion date of August 31, 2028. This research project investigates cellular stress mechanisms in osteoarthritis (OA) by examining the IRE1α-XBP1-NUPR1...
- Federal Grant Award Summary Knoubis Bio Inc. received a $312,323 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective July 15, 2025, with a completion date of June 30, 2027. The award funds the development of a novel bispecific biologic therapy for rheumatoid arthritis (RA) that targets the transmembrane tyrosine phosphatase PTPRS through its...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $487,652 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 1, 2025, through August 31, 2030. The award funds research to elucidate the effects of blood and blood-derived components on meniscus tissue homeostasis, repair, and post-traumatic...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Delaware a $666,825 Project Grant on September 1, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the structural and functional roles of muscle-subtendon units in Achilles tendinopathy. The research will extend through June 30, 2030, utilizing advanced biomechanical sensors, magnetic resonance imaging...
The University of Connecticut Health Center received a $658,289 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) on June 5, 2026, with completion targeted for March 31, 2031. This award funds the development of an engineered periarticular injection approach designed to manage knee osteoarthritis (OA) pain and improve joint health. The research addresses the clinical and economic burden of OA, which affects over 32 million Americans and currently relies on opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and steroid injections—all of which present significant safety and efficacy limitations including addiction risk and long-term complications. The project delivers a minimally invasive, non-addictive therapeutic alternative by developing periarticular (around-the-joint) injections combining local anesthetics (LA) with a pain modulator intended to provide pain relief for 6-24 weeks while improving joint health. This periarticular approach is designed to minimize complications associated with standard intraarticular steroid injections, including potential cartilage toxicity from local anesthetics. The research builds on preliminary rat model data and aims to develop a safe, effective treatment option that enables patients to participate in physical therapy while improving quality of life and reducing the economic burden of OA-related disability and lost workforce productivity.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $658.3k | 6/8/26 |