Project Grant R01AR085027
- The federal Project Grant award of $649,391 provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting research to enhance healing after injury. The overarching objective is to define the mechanisms that restrain tissue regeneration in order to develop new therapeutics to improve healing of the gut and skin following injury or infection. The 5-year project, which...
- This Project Grant award, valued at $196,460.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The purpose of the award is to test a miniature knee joint system as a new tool to study the role of neuro-immune interactions in osteoarthritis pain. The University of Pittsburgh, the awardee, will use this novel microphysiological system with cartilage,...
- This Project Grant award of $139,895.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research into the link between inflammatory arthritis and the development of cardiovascular disease. The key objectives are to investigate whether "trained immunity" - the phenomenon where innate immune cells become reprogrammed to respond more efficiently to a...
- This federal Project Grant award of $1,950,412.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), to Wake Forest University Health Sciences. The funding supports research to define how the IRE1A-XBP1-NUPR1 signaling axis in immune cells and chondrocytes contributes to synovial inflammation, cartilage damage, and osteoarthritis pain. The...
- This Project Grant award of $169,344 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research at the University of California, Davis to investigate the role of inflammation and immunomodulation in fracture healing in the context of polytrauma. The key objectives are to: (1) characterize the upregulation of inflammatory cytokines and innate...
- This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the role of reverse transendothelial migration of neutrophils in inflammation resolution. The $366,797 award, with a project period from Sep 24, 2024 to Aug 31, 2026, aims to provide new insights into the mechanisms by which certain inflammatory mediators,...
- This federal Project Grant award of $115,301 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) supports research to investigate the impact of abnormal lipid metabolism on intervertebral disc degeneration in mice. The research will comprehensively assess the mechanical properties of mouse intervertebral discs using in vivo and ex vivo testing systems, after...
- The federal Project Grant award of $426,889.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the molecular regulatory mechanisms of a cartilage-enriched G-protein coupled receptor (GPCR) named ADGRG6 and its role in maintaining joint and cartilage homeostasis. The project, awarded to the University of Southern California, aims to investigate the...
- The $735,372 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Program (CFDA 93.846) supports research to identify the key transcription factors and cytokine signals that regulate the expression of inflammatory chemokine receptors on T cells in chronic autoimmune conditions. The goal is to elucidate the dominant pathways controlling coordinated T cell migration to...
- This federal Project Grant award of $570,174 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports the development and evaluation of a zonal-specific mineralized scaffold optimal for osteochondral (OC) tissue regeneration. The research aims to mimic the hierarchical microstructure and composition of native OC tissue, which consists of articular cartilage and subchondral...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), is intended to elucidate the effects of blood and blood-derived components on meniscus tissue homeostasis, repair, and post-traumatic osteoarthritis development. The $487,652 award to Duke University will fund research to investigate the mechanisms by which blood-derived immune cells may mediate catabolism of meniscus tissue, prevent meniscus repair, and exacerbate post-traumatic osteoarthritis. The project aims to improve understanding of the direct effects of blood and blood-derived orthobiologics on meniscus tissue, which is critical to developing effective treatments for meniscus injuries. The award period is from September 1, 2025 to August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $487.7k | 8/12/25 |