This federal Project Grant award in the amount of $1,043,049.02 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award will support research at the University of Rochester focused on understanding the role of epitenon-derived progenitor cells in tendon healing and adaptation. The proposed studies will use advanced genetic lineage tracing and single-cell...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), will provide $570,878 to the University of Rochester to fund research on modulating myofibroblast dynamics during tendon healing. The goal is to define the efficacy of pharmacological activation of the GPR68 receptor to regulate the differentiation and reversion of tenocytes to...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $501,450 to The Washington University to conduct research on regulating tendon repair using stem cell-derived extracellular vesicles. The study aims to identify the specific subpopulation and active cargo molecules of extracellular vesicles that can enhance tendon healing and avoid...
The federal Project Grant award K99AR084574, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to identify the molecular and cellular mechanisms controlling tendon cell activation and regeneration after injury to the tendon-bone attachment, or enthesis. With a total funding amount of $317,211.00 awarded on July 5, 2024 and an ultimate completion date of June 30,...
This federal Project Grant award, valued at $322,408 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research under CFDA program 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research. The research aims to define how mechanically-evoked calcium signaling across 3D osteocyte networks in bone modulates the spatiotemporal remodeling of osteoblasts and osteoclasts in normal and injured conditions. The project will utilize a novel...
This federal Project Grant award in the amount of $375,100.00, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the cellular mechanisms of age-associated cortical bone remodeling. The two-year deliverables of the proposed study are: 1) identification of myeloid progenitors that aid in maintenance of cortical bone with age, and 2)...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $621,703.00 to Cornell University to conduct research focused on promoting a reparative rather than degenerative outcome from loading of fatigue-damaged tendons. The research aims to investigate the mechanisms by which glycosaminoglycans, specifically hyaluronan and dermatan sulfate,...
This federal Project Grant award of $647,460 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to identify the mechanisms responsible for the ultra-rapid induction of mechanoresponsive genes in skeletal muscle cells. The research, to be conducted by Cornell University over a 5-year period from 2024 to 2029, aims to determine how the nucleus actively...
USING COLLAGENASE TO TARGET COLLAGEN ARCHITECTURE IN FIBROTIC SKELETAL MUSCLE TO REDUCE STIFFNESS AND PROMOTE TISSUE REGENERATION. - PROJECT SUMMARY IN HEALTHY SKELETAL MUSCLE THE EXTRACELLULAR MATRIX (ECM) PROVIDES STRUCTURAL SUPPORT, FACILITATES LATERAL FORCE TRANSMISSION, AND CONTRIBUTES TO CELL SIGNALING. HOWEVER, CERTAIN MUSCLE DISEASES CAN ALTER THE ECM TO THE DETRIMENT OF MUSCLE FUNCTION. DUCHENNE MUSCULAR DYSTROPHY (DMD) IS ONE SUCH DISEASE WHICH IS CAUSED BY A MUTATION ON THE...
The University of Oregon was awarded a $360,580 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funding supports research to develop an engineered extracellular matrix (EECM) that recapitulates the anisotropic microstructure of native tendon tissue. The goal is to create a degradable, biomimetic hydrogel scaffold that can guide the alignment and...