The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $105,737 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The General Hospital Corporation (MGH) in Boston, MA. This 2-year grant aims to identify molecular and cellular mechanisms controlling tendon cell activation and regulating the divergent regenerative versus fibrotic responses in the tendon-bone attachment, or enthesis, after injury. Through a combination of multiphoton imaging, chemical and genetic approaches, and comparative studies in zebrafish and mice, the project will uncover instructive cues that may inspire novel strategies to treat enthesis injuries, which often result in scarring and high re-rupture rates in patients. The award supports a Mentored K99 phase to establish the key mechanisms driving tendon cell proliferation and recruitment, followed by an Independent R00 phase to elucidate the role of surrounding cell populations in enthesis regeneration.
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