Project Grant R01AR085156
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) will support a five-year research plan to determine the pathogenic roles of granzyme K-expressing CD8 T cells in rheumatoid arthritis synovial tissue. The $382,537 award to the University of Colorado-Denver will investigate the effector mechanisms of these T cells using in vivo, in vitro, and in situ approaches. The research...
- This Project Grant award of $139,895.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research into the link between inflammatory arthritis and the development of cardiovascular disease. The key objectives are to investigate whether "trained immunity" - the phenomenon where innate immune cells become reprogrammed to respond more efficiently to a...
- This Project Grant award of $405,350.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to characterize lipid droplets in macrophage subsets and determine if manipulating lipid droplet content can shift macrophage function, with the goal of uncovering new therapeutic targets for systemic lupus erythematosus (SLE). The award recipient is The...
- The $735,372 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Program (CFDA 93.846) supports research to identify the key transcription factors and cytokine signals that regulate the expression of inflammatory chemokine receptors on T cells in chronic autoimmune conditions. The goal is to elucidate the dominant pathways controlling coordinated T cell migration to...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $170,101 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, for a project titled "Dissecting the Spatial Heterogeneity of Synovial Inflammation in Rheumatoid Arthritis". The project aims to systematically characterize the spatial heterogeneity of synovial inflammation in rheumatoid...
- This $527,760 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will fund research on the role of endogenous retroviruses in autoimmune diseases like rheumatoid arthritis (RA). The award to the University of California, San Francisco will support a study to identify the specific antigens and mechanisms by which self-reactive T cells evade tolerance and...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $529,616 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. to conduct research on the role of Notch signaling and fibrosis in treatment-resistant rheumatoid arthritis. The project aims to define the molecular mechanisms by which Notch signaling regulates transforming growth factor beta (TGF-β) signaling in...
- This $226,932 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), provided under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the mechanisms driving the development of chronic chikungunya virus (CHIKV) arthritis (CCA). Through this project, the awardee, the University of Colorado-Denver, will conduct research to understand the role of macrophages and T cells in promoting chronic inflammation during CHIKV...
- This $548,828 Project Grant was awarded on September 21, 2023 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant was awarded to Knoubis Bio Inc., a for-profit organization based in California, to support research on a non-immunosuppressive disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis. The project aims to develop a new therapeutic approach...
- This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the role of reverse transendothelial migration of neutrophils in inflammation resolution. The $366,797 award, with a project period from Sep 24, 2024 to Aug 31, 2026, aims to provide new insights into the mechanisms by which certain inflammatory mediators,...
This Project Grant award of $320,417.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to decipher the role of complement pathways in regulating macrophage function in rheumatoid arthritis. The awardee, The Regents of the University of Colorado (doing business as the University of Colorado-Denver), will investigate the complement component signatures and responses of a specific macrophage subtype, the MERTK+HBEGF+ tissue macrophage, and how modulating these complement pathways can enhance macrophage phagocytic function and relieve inflammatory signals in the synovial tissue. This research aims to improve understanding of dysregulated macrophage function in rheumatoid arthritis and identify potential new therapeutic approaches targeting the complement system.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $320.4k | 8/12/25 |