This federal Project Grant award, valued at $715,957 and awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA Program 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, supports research to elucidate the molecular mechanisms by which interferon cytokines promote the differentiation and expansion of T peripheral helper (Tph) cells in systemic lupus erythematosus (SLE) patients. The award, with a project period from March 2025 to...
This $375,100 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funds a study to investigate the interplay between nucleic-acid-dependent phase separation and immune responses against cyclic GMP-AMP synthase (cGAS) in systemic lupus erythematosus (SLE). The research aims to determine how changes in the biophysical...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the potential impairment of hematopoietic stem cells (HSCs) as a source of hematological abnormalities and inflammation in systemic autoimmune diseases such as systemic lupus erythematosus (SLE). The $216,113 award to New York University will fund a 2-year...
This $793,093 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to define the regulatory landscape of systemic lupus erythematosus (SLE) and its cardiovascular disease (CVD) comorbidity. The grantee, Oklahoma Medical Research Foundation, will conduct systematic, high-throughput studies in macrophages derived from induced pluripotent stem cells to identify genetic variants that disrupt regulatory...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Medical University of South Carolina (MUSC) a $365,420 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to study the role of the SLE causal variant NCF1.PR90H in promoting kidney damage. The 2-year project aims to investigate how this genetic variant impacts the function of the NADPH oxidase complex and contributes to systemic lupus erythematosus...
This Project Grant award of $413,860, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to investigate the interactions between non-tuberculous mycobacteria (NTM) infections, specifically Mycobacterium abscessus (MAB), and the onset/progression of systemic lupus erythematosus (SLE). The research will utilize preclinical mouse models and ex vivo models with fetal...
This federal Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $299,937.00 to The Feinstein Institutes For Medical Research to conduct research on visualizing neural synaptic density in systemic lupus erythematosus (SLE) to better understand mechanisms of brain dysfunction. The award period runs from July 15, 2024 to July 14, 2026. The Feinstein Institutes, a non-profit research organization, will utilize this...
This federal Project Grant award of $558,045.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The grant aims to investigate how the enzyme protein phosphatase 2A (PP2A) regulates immune cell function and metabolism in the context of systemic lupus erythematosus (SLE). Key objectives include determining how PP2A controls enzymes involved in glycolysis and the pentose phosphate pathway,...
The federal Project Grant award, totaling $999,972.00, was provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to The Feinstein Institutes For Medical Research. The grant supports a study focused on "Studying Urine Macrophages in Lupus Nephritis to Shed Light on Kidney Disease Processes." The research aims to advance the understanding of lupus nephritis, a serious kidney condition, by examining immune cells in urine samples....
The University of Massachusetts Medical School was awarded a $494,929 Project Grant from the National Institute of Allergy and Infectious Diseases to study the role of Toll-like receptors, type II interferon and type III interferon in a murine model of autoinflammation. The grant will support research exploring the effector mechanisms responsible for inducing and regulating cutaneous lupus using genetically modified mice with discriminating mutations. Specifically, the researchers will use...