This federal Project Grant award of $735,460.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA Program 93.846, Arthritis, Musculoskeletal and Skin Diseases Research. The award will fund research to study the role of B cells in the pathogenesis of psoriatic arthritis (PsA), a type of inflammatory arthritis characterized by joint inflammation, bone erosion, and disability. The key objectives are to: 1) Demonstrate that proinflammatory...
This $664,933 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the cellular and molecular mechanisms of interleukin-17A (IL-17A) in the pathogenesis of psoriatic arthritis. The research aims to define the early cellular and molecular pathways that drive IL-17A-induced joint and skin inflammation, enthesitis, fingernail psoriasis,...
This federal Project Grant award of $173,880 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports a 5-year longitudinal study at Brigham & Women's Hospital Inc. to investigate the relationship between sleep quality, systemic inflammation, and disease activity in patients with psoriatic arthritis. The key objectives of the study are to: 1) determine if poor sleep...
This federal Project Grant award of $456,808.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of advanced mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in musculoskeletal tissues. The primary awardee, the Buck Institute for Research on Aging, is collaborating with researchers at the University of...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $295,294 to Biotherapeutics, Inc. for the development of a novel first-in-class topical immunoregulatory therapeutic for the treatment of plaque psoriasis. The key objectives are to: 1) evaluate the permeability and long-term stability of the topical drug product formulation, 2) compare the...
This Project Grant award of $139,895.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research into the link between inflammatory arthritis and the development of cardiovascular disease. The key objectives are to investigate whether "trained immunity" - the phenomenon where innate immune cells become reprogrammed to respond more efficiently to a...
This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the role of reverse transendothelial migration of neutrophils in inflammation resolution. The $366,797 award, with a project period from Sep 24, 2024 to Aug 31, 2026, aims to provide new insights into the mechanisms by which certain inflammatory mediators,...
This federal Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to uncover the fundamental biological and material mechanisms that control bone quality. The $1,469,862 award, with a project period from Sep 5, 2024 to Aug 31, 2029, will fund research at the University of California, San Francisco (UCSF) to investigate how exercise regulates...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA Program 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research", provides $196,460.00 to the University of Pittsburgh to develop a novel microphysiological system for studying the role of neuro-immune interactions in osteoarthritis pain. The key objectives are to: 1) understand how inflammatory molecules from synovial-like tissue impact innervating neurons,...
This Project Grant award of $170,101 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to characterize the spatial heterogeneity of synovial inflammation in rheumatoid arthritis (RA). The research aims to 1) identify the spatial underpinnings of known RA subtypes and define new spatially-informed RA subtypes, and 2) build a map of the different types of...