Project Grant R01AR084758
- This $1,024,510 National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases project grant funds research at the University of California, San Francisco into simultaneous imaging of tissue biochemistry and metabolism associated with biomechanics in patellofemoral joint osteoarthritis. The research will conduct a longitudinal cohort study of 100 individuals with isolated patellofemoral joint osteoarthritis followed over two time points. Simultaneous positron...
- The University of Pittsburgh received a $147,236 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will support a 3-year research project to quantify the mechanical effects of knee bracing and predict its ability to prevent ligamentous injuries, with a focus on the medial collateral ligament (MCL) and anterior cruciate ligament (ACL). The research...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $564,442.00 to North Carolina State University to study the impact of different surgical techniques for anterior cruciate ligament (ACL) reconstruction in skeletally immature patients. The research aims to better understand how reconstruction techniques influence joint stability and...
- This $556,160 Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846) aims to examine the efficacy of a rehabilitation approach called Rehabilitation with Exercise and Psychological Support (REPS) for patients who have undergone ACL reconstruction surgery. The REPS intervention integrates standard exercise rehabilitation with psychological support, including clinician training, patient education videos, and techniques like...
- This federal Project Grant award of $165,527 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will fund a study to characterize injury-related fear in patients after anterior cruciate ligament (ACL) reconstruction. The primary objective is to identify different trajectories of injury-related fear throughout ACL rehabilitation and understand patient perceptions of how...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is intended to support the development of pre-operative planning software for the surgical treatment of patellar instability. The $292,954 award to Ortho Haus, LLC will fund work to generate data, validate computational models, and demonstrate proof-of-concept for a software platform that...
- This federal Project Grant award for $434,682, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to precisely define the proteolytic landscape and mechanisms associated with post-traumatic osteoarthritis (PTOA). The primary objective is to improve early detection and treatment of PTOA, which is a significant public health challenge due to the...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has awarded Collamedix Inc. a $300,000 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to establish the feasibility of their "CollaLink" collagen-based scaffold for augmenting primary repair of anterior cruciate ligament (ACL) mid-substance tears. The project aims to demonstrate that the CollaLink scaffold, when placed around an ACL tear, can provide a...
- This Project Grant award of $285,630 from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support research at the University of New England (UNE) to elucidate the molecular mechanisms by which articular chondrocytes (cartilage cells) respond to mechanical forces and regulate cartilage health. The goal is to advance the understanding of the pathogenesis of osteoarthritis, a leading cause of joint pain and disability. The research objectives include establishing...
- The University of Pittsburgh received a $384,780 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to conduct research on improving cartilage regeneration for chondral defects. The project aims to evaluate the efficacy of using the compound forskolin, either through repeated injections or controlled release via microparticles, to enhance the outcomes of the...
EVALUATING OVER CONSTRAINT OF THE PATELLA FOLLOWING MPFL RECONSTRUCTION AS A CONTRIBUTING FACTOR TO PROGRESSIVE CARTILAGE DEGRADATION - PROJECT SUMMARY/ABSTRACT LATERAL PATELLAR DISLOCATION IS A COMMON TRAUMATIC INJURY FOR YOUNG, ACTIVE SUBJECTS. APPROXIMATELY 50% OF PATIENTS PROGRESS TO SYMPTOMATIC PATELLOFEMORAL POST-TRAUMATIC OSTEOARTHRITIS (PTOA) BY 25 YEARS AFTER DISLOCATION. RECONSTRUCTION OF THE MEDIAL PATELLOFEMORAL LIGAMENT (MPFL) IS CURRENTLY THE MOST POPULAR APPROACH FOR SURGICAL PATELLAR STABILIZATION. STABILIZING THE PATELLA TO PREVENT ADDITIONAL DISLOCATIONS IS GENERALLY CONSIDERED PREVENTATIVE FOR PROGRESSIVE CARTILAGE DEGRADATION THAT CAN INITIATE POST-TRAUMATIC OA, BUT PRELIMINARY DATA INDICATES ONGOING PATELLOFEMORAL CARTILAGE DEGRADATION OUT TO MULTIPLE YEARS FOLLOWING MPFL RECONSTRUCTION. PRELIMINARY DATA INDICATES OVER CONSTRAINT OF THE PATELLA FOLLOWING MPFL RECONSTRUCTION ADVERSELY INFLUENCES CARTILAGE. AIM 1 WILL CHARACTERIZE CARTILAGE DEGRADATION FOR FIFTY PATIENTS FOLLOWING MPFL RECONSTRUCTION FOR COMPARISON TO TWENTY-FIVE HEALTHY CONTROLS. THE MPFL RECONSTRUCTION PATIENTS WILL BE RECRUITED AT LEAST FIVE YEARS FOLLOWING SURGERY. ALL SUBJECTS WILL BE EVALUATED AT TWO TIME POINTS, SEPARATED BY TWO YEARS. MRI-BASED T1R/T2 RELAXATION TIME MAPPING WILL QUANTIFY CARTILAGE PROPERTIES. LONG T1R/T2 RELAXATION TIMES INDICATE CARTILAGE DEGRADATION. THE HYPOTHESIS FOR AIM 1 IS THAT CARTILAGE T1R/T2 RELAXATION TIMES FOR THE MPFL RECONSTRUCTION GROUP WILL BE LONGER THAN THE CONTROL GROUP AND INCREASE MORE DRAMATICALLY OVER TWO YEARS. ALSO, LONG T1R/T2 RELAXATION TIMES WILL BE SIGNIFICANTLY CORRELATED WITH MORPHOLOGICAL PROGRESSION TOWARD OA AS WELL AS PAIN AND POOR FUNCTION BASED ON PATIENT REPORTED OUTCOME MEASURES (PROMS). MORPHOLOGICAL GRADING WILL BE BASED ON COMPARISONS BETWEEN POST-OPERATIVE MRI AND PREVIOUSLY ACQUIRED PRE-OPERATIVE MRI. PROMS WILL BE QUANTIFIED AT EACH EVALUATION AND COMPARED TO AN EXISTING DATABASE OF PROMS ONE YEAR FOLLOWING MPFL RECONSTRUCTION. AIM 2 WILL CORRELATE CARTILAGE PROPERTIES VS. PATELLOFEMORAL CONSTRAINT TO DETERMINE IF OVER CONSTRAINT OF THE PATELLA FOLLOWING MPFL RECONSTRUCTION CONTRIBUTES TO PROGRESSIVE CARTILAGE DEGRADATION. MEASUREMENTS OF KNEE ALIGNMENT AND ANATOMY WILL CHARACTERIZE PATELLOFEMORAL CONSTRAINT. CHANGES IN ALIGNMENT FROM PRE-OPERATIVE TO POST-OPERATIVE MRI SCANS WILL BE QUANTIFIED. WEIGHT-BEARING CONE BEAM CT WILL PROVIDE ASSESSMENT OF LOADED ALIGNMENT. THE HYPOTHESIS OF AIM 2 IS THAT MEASURES INDICATING PATELLOFEMORAL CONSTRAINT WILL BE SIGNIFICANTLY CORRELATED WITH LONG CARTILAGE T1R/T2 RELAXATION TIMES AT LEAST FIVE YEARS FOLLOWING MPFL RECONSTRUCTION AND PROGRESSION OF T1R/T2 RELAXATION TIMES OVER THE NEXT TWO YEARS. THE DATA GENERATED WILL IMMEDIATELY HELP GUIDE PATIENT SELECTION AND SURGICAL PARAMETERS FOR MPFL RECONSTRUCTION TO LIMIT THE RISK OF PROGRESSIVE CARTILAGE DEGRADATION. THE DATA WILL ALSO BE USED TO DESIGN FUTURE CLINICAL STUDIES AND TRIALS FOCUSED ON COMPARING MPFL RECONSTRUCTION TO OTHER TREATMENT OPTIONS AND COMPARING BETWEEN SURGICAL PARAMETERS WITHIN MPFL RECONSTRUCTION FOR PATIENTS AT HIGHEST RISK OF PROGRESSIVE CARTILAGE DEGRADATION. THE OVERALL GOAL IS TO CREATE A TREATMENT ALGORITHM FOR PATELLAR DISLOCATIONS THAT EMPHASIZES CARTILAGE PRESERVATION.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $195.2k | 5/19/25 | ||
| Not listed | $0 | 12/24/24 | ||
| Not listed | $0 | 12/24/24 | ||
| Not listed | $161.0k | 7/31/24 | ||
| Not listed | $161.0k | 7/31/24 |