This Project Grant award of $405,350.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to characterize lipid droplets in macrophage subsets and determine if manipulating lipid droplet content can shift macrophage function, with the goal of uncovering new therapeutic targets for systemic lupus erythematosus (SLE). The award recipient is The...
This federal Project Grant award of $216,113.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to characterize hematopoietic stem cell (HSC) impairment in a mouse model of systemic lupus erythematosus (SLE)-like disease. The research aims to understand how clinical SLE-like disease affects HSC activity, which may contribute to hematological...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $715,957 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Northwestern University to investigate the molecular mechanisms by which type I interferon supports the production and expansion of T peripheral helper (Tph) cells in systemic lupus erythematosus (SLE) patients. The research project aims to utilize cutting-edge biochemical, epigenetic, and genetic approaches to...
This $375,100 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funds a study to investigate the interplay between nucleic-acid-dependent phase separation and immune responses against cyclic GMP-AMP synthase (cGAS) in systemic lupus erythematosus (SLE). The research aims to determine how changes in the biophysical...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Medical University of South Carolina (MUSC) a $365,420 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to study the role of the SLE causal variant NCF1.PR90H in promoting kidney damage. The 2-year project aims to investigate how this genetic variant impacts the function of the NADPH oxidase complex and contributes to systemic lupus erythematosus...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the long-term systemic consequences of type 2 skin inflammation on epithelial stem cells. The $242,310 award to Rockefeller University will fund a 2.5-year study to define the specific cell-intrinsic mechanisms and niche signaling that underlie the...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $599,693 to The Hospital For Special Surgery Fund, Inc. (HSS Foundation) from August 1, 2024 to July 31, 2029. The award supports research to elucidate molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis, with the goal of developing new...
This Project Grant award of $147,400.00, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the mechanisms by which antigen non-related CD4+ T cells contribute to the pathogenesis of skin fibrosis in systemic sclerosis (scleroderma) and sclerodermoid graft-versus-host disease. The project, conducted by Yale University, will use mouse models to...
The National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $409,311.92 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) from April 5, 2021 to January 25, 2022. The project grant funding supports research into the role of T follicular helper (TFH) cells in the pathogenesis of dermatomyositis, a severe inflammatory myopathy. Specifically, the award will fund studies to...
This $1,540,008 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports an Integrated Program for Cutaneous Immune-Stromal Interactions in Systemic Lupus Erythematosus (IPCISS) at the University of Michigan. The program aims to further define the critical role of skin and immune-stromal interactions in systemic lupus erythematosus pathogenesis, with a focus on how spatial...