This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate mechanisms that can transform everyday activity into a reparative stimulus for the treatment of tendinopathies. The $621,703 award to Cornell University, with a period of performance from Sep 1, 2024 to Aug 31, 2029, will fund studies to determine how...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $206,023 to Cornell University to investigate the mechanotransduction pathways in injured cartilage. The goal is to leverage a novel spatiotemporal analysis tool called STRAINS to study the real-time response of chondrocytes (cartilage cells) to impact trauma. The research aims to...
This federal Project Grant award, totaling $1,034,838.00 and made by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the physiological function of neutrophil serine proteases in the muscle stem cell niche and the underlying molecular mechanisms. The award was granted to The Research Foundation For The State University Of New York, doing business as Stony...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $151,471.00 to the University of California, Davis to conduct research on using collagenase to target collagen architecture in fibrotic skeletal muscle. The goal is to reduce muscle stiffness and promote tissue regeneration, particularly in the context of Duchenne muscular...
This Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to investigate the role of netrin signaling in regulating muscle stem cell quiescence and activation. The $626,483 award, effective from August 1, 2024 to May 31, 2026, will support the Icahn School of Medicine at Mount Sinai in conducting in vivo and ex vivo studies to...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the novel role of HOX-expressing interstitial cells in skeletal muscle growth, homeostasis, and regeneration. The $557,357 award to the University of Wisconsin-Madison will fund a 5-year research project to utilize genetic tools and multi-omic approaches to...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the functional roles of microRNA-320 in skeletal muscle. The $374,204 award to The Leland Stanford Junior University will be used to: 1) Characterize the phenotype of microRNA-320 knockout mice, examining muscle size, fiber type, and contractile force; 2)...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $525,259.51 to the University of Rochester to conduct research on the role of epitenon-derived progenitor cells in tendon healing and adaptation. The research aims to create a comprehensive atlas defining the pathways regulating the coordinated mechanoresponse of epitenon cells,...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $522,714 Project Grant (CFDA 93.846) to Rensselaer Polytechnic Institute (RPI) to research new mechanisms behind skeletal muscle endurance, specifically related to stretch activation. The project aims to test the hypothesis that stretch activation is a critical factor for maintaining force production and endurance in mammalian skeletal muscle. Experiments will measure stretch activation characteristics...
This $488,575 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to understand how myosin binding protein-C (MYBP-C) regulates skeletal muscle contraction and how genetic mutations in MYBP-C cause skeletal muscle diseases. The University of Arizona, the grant recipient, will use a novel "cut and paste" method to...