This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $649,391 to The Johns Hopkins University to conduct research aimed at enhancing healing after injury that is often slow and incomplete. The goal is to define the mechanism of injury response pathways that restrain healing, with the hope of developing new therapies to improve...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $926,078 to The Ohio State University to conduct research on the role of autoantibodies against membrane repair proteins in the development and progression of idiopathic inflammatory myopathies (IIM). The research aims to define the mechanistic impact of these autoantibodies, determine if...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has awarded a $383,570 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Trustees of Indiana University, doing business as Indiana University Indianapolis. The grant, titled "Delineating the Contribution of Muscle Wasting to Tumor Progression," aims to better understand the relationship between skeletal muscle wasting and tumor progression in cancer patients. The...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,037,340 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The Broad Institute, Inc. The purpose of this grant is to transform the Musculoskeletal Knowledge Portal (MSKKP) into an established biomedical knowledgebase. The project aims to integrate diverse omics datasets curated by musculoskeletal research experts and process them through analytical...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $626,483 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the Icahn School of Medicine at Mount Sinai. The grant, with a period of performance from August 1, 2024 to May 31, 2026, will support research to determine the role of Netrin-1 signaling in regulating muscle stem cell quiescence and activation. The research aims to validate the use of a new ex vivo live...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) supports research to investigate the pathogenesis of immune checkpoint inhibitor (ICI)-induced myocarditis. The Johns Hopkins University received $547,945 to conduct this 5-year project starting on January 1, 2025. The key objectives are to: 1) examine how biological factors like prior cardiac injury, age, and sex influence the risk of ICI-myocarditis by modulating cardiac-resident memory...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $599,693 to support research into the negative regulation of osteoclastogenesis - the process of generating bone-resorbing cells. The overarching goals are to elucidate the molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis under...
This federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is provided to Trustees of Indiana University, doing business as Indiana University Indianapolis, to conduct research on targeting the gene KLF10 to prevent cancer-associated muscle loss. The $239,239 award, with a period of performance from September 18, 2023 to August 31, 2024, aims...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $375,100 to The Johns Hopkins University to conduct research on the interplay between nucleic-acid-dependent phase separation and immune responses against cGAS in systemic lupus erythematosus (SLE). The research aims to delineate how biophysical changes triggered by cGAS...
This $557,357 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into a novel subset of muscle progenitor cells expressing Hox genes. The primary focus is to interrogate the potential of these Hox-expressing interstitial cells to contribute to muscle growth, homeostasis, and regeneration using in vivo and in vitro approaches. Key...