Project Grant R01AI202121
- The National Institute of Allergy and Infectious Diseases awarded $787,945 to the Regents of the University of California, doing business as University of California, Berkeley, on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research defines the specificity requirements and functional properties of regulatory T cells (Tregs) that maintain tolerance to the microbiota, with emphasis on RORγt+ Tregs generated during the peri-weaning period in mice...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $717,745 on June 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on T cell development and thymic selection mechanisms. The research, titled "Tuning TCR Signaling and Cell Fate During Thymic Selection," investigates how T cells achieve self-tolerance while maintaining responsiveness to foreign pathogens...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $201,744 on June 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support a five-year research and training project investigating the distinct roles of NR4A1 and NR4A3 transcription factors in thymic T cell tolerance. The research aims to understand how NR4A transcription factors—whose expression scales with self-reactivity—translate T...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $874,531 on May 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to model dynamic CD8+ T cell–virus interactions in post-treatment control of HIV. The project comprehensively defines mechanistic features of CD8+ T cell responses that most strongly relate to control of HIV after stopping antiretroviral therapy. Research will examine...
- The National Institute of Allergy and Infectious Diseases awarded J. David Gladstone Institutes $3.601 million on February 6, 2026, to investigate transcriptional and post-transcriptional regulation of human regulatory T cell identity and function under the Allergy and Infectious Diseases Research program (CFDA 93.855). The work targets the gene regulatory networks controlling Treg stability, with a focus on how the transcription factor FOXP3 maintains immune homeostasis and prevents...
- The National Institute of Allergy and Infectious Diseases awarded the University of California Irvine $431,750 on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the functional expansion of regulatory T cells to limit central nervous system autoimmunity. The research investigates key principles of regulatory T cell (Treg) expansion to address pathophysiology in CNS autoimmune conditions and promote myelin repair. The work employs...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $842,888 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify immunological and transcriptional factors associated with treatment outcomes in drug-susceptible tuberculosis. The recipient will conduct transcriptional profiling of whole blood to define pathways and genetic regulatory networks associated with shorter time...
- The National Institute of Allergy and Infectious Diseases awarded $201,744 to The Regents of the University of California, San Francisco on April 15, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund research into transcriptional mechanisms that drive dysregulated type 17 mucosal inflammation via innate lymphoid cells. The project investigates how group 3 innate lymphoid cells (ILC3s) trigger and sustain aberrant type 17 immune responses in chronic...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $441,202 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, doing business as University of California, Berkeley, with an award date of June 12, 2025 and completion date of May 31, 2027. The grant funds basic immunological research investigating the role of ex-regulatory T cells (exTregs) in...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the Department of Health and Human Services, awarded $504,547 to The Regents of the University of California, San Francisco (UCSF) on August 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant T32AI200899). The award funds the UCSF Immunology Training Program (ITP), which provides structured training to approximately 5–6 graduate students per year (3 per cohort) and 2–3...
The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $813,236 on August 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to elucidate cell signaling determinants of human regulatory T cell (Treg) persistence. The research investigates mechanisms controlling Treg survival and function, focusing on improved persistence as a barrier to therapeutic efficacy in Treg cell therapies for autoimmune, transplantation, and inflammatory diseases. The project examines signaling downstream of autocrine IL-2 receptor-tethered IL-2 (AUTO2) constructs in sustaining human Treg persistence by characterizing STAT5, PI3K, and MAPK activation across various AUTO2 constructs and relating these activities to efficacy in supporting Treg persistence in vitro and in immunodeficient mice models. The work also builds on prior genome-wide CRISPR screens identifying AP1 family transcription factors and upstream signaling hubs controlling Treg persistence. Performance occurs in San Francisco, California, with a period of performance extending through July 31, 2031. The assistance type is a project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $813.2k | 8/17/26 |