Project Grant R01AI202117
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Idaho $505,406 on June 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate cell form determination during the chlamydial intracellular infectious cycle. The award funds research into the mechanisms regulating distinct developmental cell forms—the reticulate body (RB),...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $816,421 on April 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study the interplay of heterosexual male-female partner microbiomes, Chlamydia trachomatis infection, and transmission dynamics. The research addresses a gap in knowledge about urethral C. trachomatis infections in men who have sex only with women and transmission to...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Davis $404,570 on February 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify and validate target antigens recognized by protective Chlamydia-specific memory CD4 T cells and to examine whether an mRNA vaccine approach can provide protection in a mouse model. This work addresses antigen identification for Chlamydia vaccine development; Chlamydia trachomatis...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $431,750 Project Grant to the University of California, Irvine under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period August 1, 2025 through July 31, 2027. The research project focuses on developing and validating new complementation tools and conditional expression methods to enhance genetic approaches for studying Chlamydia trachomatis virulence determinants....
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $717,952 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate host lipid acquisition and the maintenance of the Chlamydia replicative niche. The research addresses Chlamydia trachomatis infection, the leading cause of bacterial sexually transmitted infections, for which no vaccine exists. The project will test the hypothesis that a single...
- The National Institute of Allergy and Infectious Diseases awarded $435,875 to Trustees of Indiana University (Indiana University Indianapolis) on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how Chlamydia-infected cells affect non-infected bystander host cells and identify intervention points that could promote clearance of Chlamydia trachomatis without broad-spectrum antibiotics. The research addresses the mechanisms underlying...
- The National Institute of Allergy and Infectious Diseases awarded Thomas Jefferson University $558,367 on September 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the regulation of cytoskeletal reorganization by Chlamydia trachomatis. The research investigates how Chlamydia trachomatis, an intracellular bacterium responsible for sexually transmitted infections and infectious blindness, hijacks host cell cytoskeletal pathways to...
- The National Institute of Allergy and Infectious Diseases awarded the Board of Regents of the University of Nebraska $417,845 on June 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate post-translational modulation of host purine biosynthetic enzymes by Chlamydia trachomatis. The project, designated R21AI199320, examines how Chlamydia trachomatis, an obligate intracellular bacterium, manipulates host cell GTP biosynthesis to support its own growth....
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Virginia a Project Grant of $450,766 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 8, 2025, with completion targeted for July 31, 2027. This research initiative aims to characterize how Chlamydia trachomatis, the leading cause of bacterial sexually transmitted infections, remodels inter-organelle communication within host cells to create a...
- The National Institute of Allergy and Infectious Diseases awarded $138,903 to the University of California, San Diego on January 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify and characterize novel transcriptional regulators associated with antiphage immune systems in clinically important bacterial pathogens. The funded research focuses on gene regulation within bacterial defense islands. The recipient will define the upstream signals and...
The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded the University of California Irvine $760,663 on August 7, 2026, for a Project Grant (R01AI202117) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will conduct research into the regulatory mechanisms controlling production of infectious elementary bodies (EBs) in Chlamydia trachomatis, the causative agent of the most commonly reported bacterial sexually transmitted infection in the United States. The project spans three coordinated aims. Aim 1 examines how a chlamydia-specific transcription factor, EUO, represses late genes required for RB-to-EB conversion until late stages of the developmental cycle, when EUO dimers convert to inactive monomers and allow gene expression. Aim 2 studies an alternative RNA polymerase sigma factor, S28, and its sequestration by an anti-sigma factor, RSBW, until late times permit S28-dependent transcription of target genes. Aim 3 tests a model that a Type 3 Secretion chaperone, SCC2, silences transcription in EBs and activates chlamydial transcription in a T3S-dependent manner upon host cell entry. Performance of work will occur in Irvine, California. The period of performance runs from August 7, 2026, through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $760.7k | 8/7/26 |