Project Grant R01AI201440
- The National Institute of Allergy and Infectious Diseases awarded the University of Arizona $806,740 on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize the mechanisms by which natural environmental agents from traditional Amish farms protect the lungs against rhinovirus infection and associated asthma development in children. The research investigates how early-life exposure to cow barn environments and barn-derived substances present...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $825,786 on July 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how diet-mediated gut microbiome interactions influence early-life susceptibility to respiratory infection and childhood asthma risk. The research project, titled "Determining Diet by Microbiome Interactions That Mitigate Early Life Susceptibility to...
- The National Institute of Allergy and Infectious Diseases awarded Mayo Clinic Arizona $638,403 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the roles of group 2 innate lymphoid cells (ILC2s) in type 2 immunity and asthma. The project examines immunological mechanisms underlying airway inflammation in asthma patients, focusing on how ILC2s—which rapidly produce type 2 cytokines—regulate adaptive immune responses in the lungs and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Arizona a Project Grant of $3,075,549 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 28, 2025, with a completion date of June 30, 2029. This research initiative investigates airway innate immune responses to Coccidioides infection, a serious fungal disease commonly known as valley fever that is expanding geographically across the United States. The research focuses on...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $598,906 on April 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms of respiratory viral infections in hospitalized children. The research examines how early-life respiratory tract infections contribute to asthma development by analyzing nasal transcriptomes in children hospitalized with bronchiolitis or asthma. The project team...
- The National Institute of Allergy and Infectious Diseases awarded Arizona State University $429,997 on June 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to engineer inducible morphotype switching control in Mycobacterium abscessus for investigating infection outcomes and discovering pathophysiological-targeted treatments. The project leverages CRISPR interference (CRISPRi) and anhydrotetracycline-inducible tetr-regulated promoter-operator systems to create...
- The National Institute of Allergy and Infectious Diseases awarded the University of Wisconsin–Madison $1,650,321 on August 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct longitudinal research on early life epithelial development and asthma risk through the Childhood Allergy and the Neonatal Environment (CANOE) study. The award funds analysis of serial nasal cell samples collected from study participants beginning at birth through age 5 years to...
- The National Institute of Allergy and Infectious Diseases awarded the University of Arizona $237,660 on January 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the underlying biology of broadly neutralizing antibodies. The recipient will conduct research to determine what properties define broadly neutralizing antibodies, testing the hypothesis that most such antibodies are broad because they are rare rather than because they target conserved...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $100,228 on December 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on microbe-induced immune alterations that protect against allergic airway eosinophilia. The research tests the hypothesis that inhalation exposure to Streptococcus pneumoniae confers protection against allergic airway eosinophilia—excessive eosinophil recruitment to...
- The National Institute of Allergy and Infectious Diseases awarded the University of Arizona $368,681 on May 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to establish and expand the National Summer Undergraduate Research Project (NSURP), an eight-week virtual summer research program in biomedical microbiology and immunology. NSURP matches underrepresented minority undergraduate students nationwide with faculty mentors to conduct remote research from any...
The National Institute of Allergy and Infectious Diseases awarded the University of Arizona $797,394 under Project Grant R01AI201440 on August 1, 2026, to define mechanistic pathways through which infant gut microbial metabolites affect immune responses to airway viral infection and aeroallergens, and to assess their impact on airway barrier integrity. Funding supports the Allergy and Infectious Diseases Research program (CFDA 93.855). The research builds on preliminary findings from the Binational Early Asthma and Microbiome Study (BEAMS-1), which identified a fourfold difference in childhood asthma rates between infants living in Nogales, Mexico, and Tucson, Arizona despite comparable Mexican ancestry and geographic proximity. Earlier work linked dietary lipid stool metabolites to asthma-predictive symptom scores in six- to nine-month-old infants, with oleic, palmitic, and linoleic acid metabolites enriched in high-risk infants and polyunsaturated fatty acids enriched in low-risk infants. The investigator proposes to test how sterile fecal extracts from BEAMS infants with distinct symptom scores differentially regulate viral load, antiviral immune responses, and allergen-specific immunity using mouse models of human rhinovirus infection and aeroallergen exposure. The award covers the period August 1, 2026, through July 31, 2031, with place of performance in Arizona. The University of Arizona is operating as the Arizona Board of Regents.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $797.4k | 8/1/26 |