Project Grant R01AI198970
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Jackson Laboratory $486,750 under the Aging Research program (CFDA 93.866) for a two-year project beginning September 1, 2025, and concluding August 31, 2027. This Project Grant funds research investigating the impact of age-related clonal hematopoiesis (CH)—a condition in which blood-forming stem cells accumulate somatic mutations that provide selective growth advantages—on Alzheimer's disease (AD) pathology onset...
- Grant Award Summary The Jackson Laboratory received a $716,579 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective December 15, 2025, with completion scheduled for November 30, 2030. The award funds a comprehensive research initiative investigating the genetic mechanisms underlying microglia-mediated synapse loss in Alzheimer's disease. The project employs genetically engineered mouse models and multi-modal genetic...
- Federal Grant Award Summary Fred Hutchinson Cancer Center received a $190,944 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 8, 2025, with completion targeted for July 31, 2027. The grant supports systematic investigation of B cell dynamics and immune memory formation in human vaccination, specifically examining how different immunostimulatory adjuvants influence B...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Jackson Laboratory a $704,636 Project Grant under the Cancer Biology Research program (CFDA 93.396) on May 14, 2026, with an ultimate completion date of April 30, 2031. This award funds fundamental research investigating pre-leukemic hematopoietic stem cell (HSPC) clonal selection by the adaptive immune system, with the objective of identifying immuno-preventative strategies to intercept leukemogenesis at its...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant totaling $159,300 to the La Jolla Institute for Immunology under the Allergy and Infectious Diseases Research program (CFDA 93.855) on April 2, 2026. The award funds a five-year research initiative examining human upper airway immune memory kinetics and durability against respiratory pathogens, with a completion date of March 31, 2031. The research addresses critical...
- Federal Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $813,921 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded February 19, 2026, with a completion date of January 31, 2031. The research project aims to elucidate trained immunity mechanisms induced by messenger ribonucleic acid-lipid nanoparticle (mRNA-LNP) vaccines and...
- Federal Grant Award Summary The Johns Hopkins University received a $197,600 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) for research spanning September 21, 2025 through April 30, 2027. The project, titled "Identifying Metabolic Targets to Reinvigorate T Cell Exhaustion," focuses on investigating the metabolic mechanisms underlying CD8+ T cell dysfunction that occurs...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded La Jolla Institute for Immunology a $929,095 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) beginning June 2, 2026, with a completion date of May 31, 2031. This award funds research to advance understanding of lymphoid tissue immunology in systemic lupus erythematosus (SLE) patients and the impact of therapeutic interventions. The research...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a Project Grant totaling $1,285,304 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and evaluate an enhanced HIV vaccine regimen capable of producing durable broadly neutralizing antibody (BNAB) responses. The research, which commenced August 1, 2025, and extends through July 31, 2030, leverages a novel six-shot germline-targeting...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $780,787 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective January 27, 2026, with completion targeted for December 31, 2030. The award supports fundamental research aimed at understanding how T cell receptor (TCR) recognition of peptide ligands shapes memory CD8+ T cell programming, with...
The Jackson Laboratory received a $932,993 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 2, 2026, with completion targeted for May 31, 2031. This research initiative examines trained immunity signatures and reduced vaccine responses in older adults by investigating epigenetic remodeling of hematopoietic stem and progenitor cells (HSPCs). The project leverages a longitudinal cohort of 62 older adults vaccinated with different influenza vaccine platforms over three consecutive seasons and employs the PBMC-PIE (Peripheral Blood Mononuclear Cell-Progenitor Interrogation Enrichment) platform to profile circulating HSPCs at single-cell resolution from cryopreserved samples, thereby enabling investigation of progenitor cell states without requiring bone marrow biopsies. The research deliverables are structured across three specific aims: identifying molecular and epigenomic features that distinguish strong from poor vaccine responders; determining how different influenza vaccine platforms (high-dose, adjuvanted, and recombinant) shape chromatin landscapes and lineage bias in HSPCs; and testing whether maladaptive aged HSPC states can be rejuvenated in vitro using immunomodulatory factors. By linking blood-based epigenetic signatures to real-world immune outcomes, this work aims to advance understanding of immune heterogeneity in aging and generate novel biomarkers and potential therapeutic interventions for improving vaccine responsiveness in older populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $933.0k | 6/3/26 |