Project Grant R01AI197956
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Wistar Institute of Anatomy and Biology a $162,000 Project Grant (CFDA 93.855: Allergy and Infectious Diseases Research) effective February 5, 2026, through January 31, 2028, to support research defining the single-cell epigenetic landscape of the HIV-1 reservoir for effective latency reversal. The research addresses a critical gap in HIV cure science by investigating how proviral...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $489,500 to The Children's Hospital of Philadelphia Research Institute on June 11, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This two-year project, which extends through May 31, 2027, focuses on developing novel sequencing methodologies and analytical pipelines to identify and characterize intact human immunodeficiency virus (HIV) reservoir cells...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded University of California, Los Angeles $3.15 million through the Allergy and Infectious Diseases Research program (CFDA 93.855) for a four-year project (July 1, 2026–June 30, 2030) focused on developing hematopoietic stem/progenitor cell (HSPC)-based chimeric antigen receptor (CAR) immunotherapy targeting HIV. The project delivers research and development services aimed at creating a...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Wistar Institute of Anatomy and Biology a Project Grant of $888,042 under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2026, through June 30, 2031. The research investigates N332-glycan-independent V3-glycan antibodies as novel targets for HIV-1 vaccine design, with the goal of developing broadly neutralizing antibodies (BNAbs) that achieve...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, Los Angeles a $783,740 project grant on July 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to advance engineered cellular immunotherapy for HIV-1 infection. The research initiative, titled "Targeted Enhancement of Engineered Cellular Anti-HIV Immunity In Vivo Using Immune Modulators," extends through June 30,...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Wistar Institute of Anatomy and Biology a $506,550 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 11, 2026, with completion targeted for May 31, 2028. This research initiative focuses on neutralizing persistent Type-I Interferon signaling to augment HIV-specific Chimeric Antigen Receptor (CAR) T cell therapy. The primary deliverables include mechanistic studies...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $446,875 to the University of Pennsylvania on July 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to advance acceptability and ethical readiness for innovative HIV cell and gene therapies in the United States. The project, which will be completed by June 30, 2028, addresses critical gaps in the implementation of cell and gene therapy (CGT)...
- Federal Project Grant Award Summary The Wistar Institute of Anatomy and Biology received a $506,550 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 1, 2026, with completion scheduled for May 31, 2028. This research grant funds a cross-sectional study designed to identify host plasma biomarkers and SomaLogic disease prognosis scores associated with cell-associated human...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $473,491 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 3, 2026, with completion targeted for May 31, 2028. The grant funds development and testing of logic-gated chimeric antigen receptors (CAR) designed to selectively target and eliminate latently HIV-infected CD4+ T cells...
- Summary of Federal Project Grant Award The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Alabama at Birmingham $2.55 million under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 18, 2025, for a multi-project research initiative focused on developing novel cell and gene therapy approaches for HIV cure. The award, with an ultimate completion date of June 30, 2030, supports an integrated research program led by investigators...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Wistar Institute of Anatomy and Biology a $707,928 Project Grant (CFDA 93.855: Allergy and Infectious Diseases Research) on July 13, 2026, to develop epitope-engineered hematopoietic stem cells (HSCs) enabling chimeric antigen receptor (CAR) T cell-mediated CD4 depletion for HIV cure. The research combines autologous hematopoietic stem cell transplantation (HSCT) with precision genome editing to create HIV-resistant immune cells while preserving immune function. Using base editors, the project introduces functionally silent mutations in CD4—the primary HIV entry receptor—to generate immune cells broadly resistant to both CCR5-dependent and CCR5-independent HIV strains. In parallel, engineered CD4 variants render base-edited cells resistant to CAR T cell-mediated depletion, enabling selective elimination of residual wild-type CD4+ cells harboring HIV reservoirs following HSCT. This approach addresses critical limitations of existing allogeneic transplantation methods by establishing a protected immune compartment while permitting targeted eradication of persistent infected cells that drive viral rebound after antiretroviral therapy interruption. The award extends through June 30, 2031, and is positioned within NIAID's broader portfolio of infectious disease research, which emphasizes innovative translational and basic science addressing urgent health challenges. Deliverables include development of CD4-modified HSCT approaches and related research outputs supporting HIV cure strategy advancement.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $707.9k | 7/13/26 |