Project Grant P01AI191224
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $3,643,653 project grant to the University of Pennsylvania on July 8, 2025. The goal of this 5-year program is to develop a chimeric antigen receptor (CAR) T-cell approach that can control HIV replication below detectable levels and eliminate the viral reservoir, despite the continued medical and economic burden of HIV. The project...
- This $128,451 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports a research project led by the University of Alabama at Birmingham (UAB) to investigate the structural basis for how the HIV-1 Rev protein is recognized, bound, and trafficked through the nuclear pore complex by the host's nuclear transport machinery. The project aims to decipher the specific mechanisms by...
- The University of Alabama at Birmingham (UAB) was awarded a $738,030 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) to serve as a Regional Consultation Hub for Precision HIV Implementation Science towards Ending the HIV Epidemic. Over the 5-year project period from 2025-2030, the UAB HIV Implementation Science Hub will provide technical consulting, training, and collaborative opportunities to support...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $295,276 Project Grant to the University of Chicago under the Allergy and Infectious Diseases Research program (CFDA 93.855) on January 18, 2025. The grant supports a computational research project investigating the assembly and disassembly processes of the HIV-1 virus, including the budding of the immature virion, maturation of the viral core, and uncoating. The research aims to gain a mechanistic understanding of these...
- This federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $486,057 award supports the development of a multipronged mRNA gene therapy approach to address the challenge of pathogen persistence and latent viral infection, with a specific focus on developing a cure for HIV. The key products and services to be delivered include: 1) mRNA-based delivery of the viral...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $742,499 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Alabama at Birmingham (UAB). The grant supports research focused on investigating siderophore secretion and drug efflux mechanisms in Mycobacterium tuberculosis. Key objectives include shedding light on the unique secretion system in M. tuberculosis and revealing the molecular mechanisms driving...
- The University of South Alabama was awarded a $431,147 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The 2-year grant, awarded on July 1, 2025, supports research to investigate the mechanisms controlling monoclonal antibody (mAb)-induced infusion reactions, a common and potentially severe side effect of mAb therapies. The research aims to improve understanding of the...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $791,661 Project Grant to Duke University. This 5-year grant, effective August 1, 2025 through July 31, 2030, will support research to optimize a vaccine delivery platform and multi-antigen strategy to elicit durable neutralizing antibodies and T-cell responses against HIV-1 infection. The research will leverage integrase-defective...
- This federal Project Grant award of $162,486 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) is funding research to engineer B cells for enhanced control of HIV. The key goals are to: Design synthetic protein signaling molecules to enhance B cell functions that are typically deficient in people living with HIV, such as T cell help. Evaluate the ability of these engineered B cell stimulants to drive critical B cell...
- The federal Project Grant award for "IL-15 THERAPY COMBINED WITH TGF-BETA BLOCKADE FOR SUSTAINED HIV REMISSION" is funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $800,389 grant aims to evaluate the safety and therapeutic potential of a novel strategy towards a cure for HIV infection. The proposed treatment combines soluble IL-15/IL-15RA-FC with a TGF-β pathway blockade and...
The University of Alabama at Birmingham (UAB) was awarded a $2,545,881 Project Grant under the National Institute of Allergy and Infectious Diseases' (NIAID) Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports a multi-project research program to develop and implement an emerging gene and cell therapy technology for HIV cure. The program aims to demonstrate that HLA-E-peptide complexes on HIV-infected cells can be targeted by antibodies, natural killer cells, or CD8+ T cells, leading to clearance of HIV infection. Key objectives include producing novel HLA-E-HIV peptide-specific T cell receptors and chimeric antigen receptors, and evaluating their in vitro specificity and antiviral function. The award has a performance period from August 2025 through June 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.5m | 8/22/25 |