Project Grant R01AI201152
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $473,491 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 3, 2026 through May 31, 2028. The grant supports the development and testing of logic-gated chimeric antigen receptors (CAR) designed to selectively target and eliminate latently HIV-infected CD4+ T cells based on phenotypic markers...
- Summary of Federal Project Grant Award The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Alabama at Birmingham $2.55 million under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 18, 2025, for a multi-project research initiative focused on developing novel cell and gene therapy approaches for HIV cure. The award, with an ultimate completion date of June 30, 2030, supports an integrated research program led by investigators...
- Federal Project Grant Award Summary Fred Hutchinson Cancer Center received a $862,398 Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025 through July 31, 2030. The award supports the development of novel Chimeric Antigen Receptor (CAR) T cell therapeutics designed to selectively target and deplete the HIV latent reservoir, specifically programmed cell death protein 1...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Southern California a $14.74 million Project Grant on September 5, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop innovative in vivo cell engineering strategies for an HIV cure. The research program, structured as a multi-project initiative with three interacting projects (KIEM, CANNON, and SCADDEN), leverages recent advances in gene and cell therapy...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $874,531 to The Regents of the University of California, San Francisco on May 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research modeling dynamic CD8+ T cell-virus interactions in post-treatment control of HIV. The project, which extends through April 30, 2031, addresses a critical gap in understanding which mechanistic features of CD8+...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $489,500 to The Children's Hospital of Philadelphia Research Institute on June 11, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This two-year project, which extends through May 31, 2027, focuses on developing novel sequencing methodologies and analytical pipelines to identify and characterize intact human immunodeficiency virus (HIV) reservoir cells...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a $253,256 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to establish preclinical platforms for engineered B cell therapies targeting HIV. The award, effective June 1, 2026 through May 31, 2028, funds research aimed at developing a functional HIV cure that maintains lifelong viral suppression without antiretroviral therapy....
- Federal Project Grant Award Summary The University of California, San Diego received a $718,637 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 24, 2026, with completion targeted for January 31, 2031. This research project delivers scientific investigation and development services focused on evaluating camptothecin analogs as "block and lock" therapeutic...
- Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $121,182 Project Grant to the University of California, San Diego (UCSD) on December 5, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research investigating how vaccine formulations influence germinal center dynamics and antibody response development, with completion scheduled for February 3, 2028. This research addresses the critical challenge of...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of North Carolina at Chapel Hill a $427,625 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective June 15, 2026, through May 31, 2028. This award funds comprehensive research to identify immune signatures associated with human immunodeficiency virus (HIV) reservoir characteristics and clonal expansion in antiretroviral therapy...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded $3.15 million to the University of California, Los Angeles for a four-year project (July 1, 2026 – June 30, 2030) to develop hematopoietic stem/progenitor cell (HSPC)-based chimeric antigen receptor (CAR) immunotherapy targeting HIV cure. The research aims to genetically modify autologous hematopoietic stem cells with anti-HIV CAR molecules to enhance and optimize anti-HIV cellular immune responses, potentially enabling lifelong immune protection and HIV clearance without the limitations of current antiretroviral therapy. The project deliverables include optimization of CAR-modified stem cell engraftment using clinically relevant conditioning methods, maintenance of long-term progenitor phenotype for repopulation capability, characterization of differentiation and therapeutic effects using humanized mouse models, and development of an in vivo targeting regimen using stem cell-targeted nanocapsules to generate CAR-modified stem cells in vivo. The research is designed to provide crucial insights for investigational new drug (IND) development of HSPC-based CAR immunotherapies, advancing toward potential ART-free functional cure strategies for HIV infection.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 7/1/26 |