Project Grant R01AI195802
- The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $512,842 on July 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how capsule O-acetyltransferases modulate pneumococcal fitness and contribute to bacterial virulence. The research focuses on characterizing the function of capsule polysaccharide O-acetyltransferase enzyme families in Streptococcus pneumoniae and their role in coordinating with...
- The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $223,500 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate Group A Streptococcus-induced autoimmune complexes and post-streptococcal sequelae. The research examines the autoimmune mechanisms underlying post-streptococcal disorders including rheumatic heart disease, rheumatic fever, post-strep arthritis, post-strep...
- The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $490,611 on April 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of regulatory dendritic cells in neonatal immune responses to influenza infection. The research examines how a newly identified form of dendritic cell maturation (mREGDC1) impairs protective CD8 T cell responses in newborns and young infants during respiratory viral...
- The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $496,628 on February 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on FC receptor-like (FCRL) regulation in B cell tolerance and malignancy. The research investigates mechanistic roles of FCRL molecules in B cell pathology, with emphasis on chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL). B lineage cells account for...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of South Alabama a $431,147 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year period from July 1, 2025, through June 30, 2027. The research project, titled "Innate Immune Regulation of Monoclonal Antibody-Induced Infusion Reactions," addresses the mechanisms underlying adverse immune reactions that occur during...
- The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $131,307 on October 21, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize the structural and functional roles of pili produced by Burkholderia cepacia complex bacteria in cystic fibrosis infection. The research will elucidate the dynamics of BCC pili production and their contribution to bacterial adherence, colonization, and biofilm formation in...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded Emory University $100,228 on November 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into autoreactive, extrafollicular B cell pathways in a TLR7-driven murine model. The project addresses gaps in understanding the origins of extrafollicular effector B cells and the system-wide and microenvironmental signaling that...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Los Angeles $744,483 on June 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how epigenetic heterogeneity and temporal signaling dynamics in B-cell selection shape antibody repertoires and vaccine responses. The funded research examines B-cell fate decisions during antibody-mediated immunity through two primary aims. Aim 1 investigates how dynamic...
- Federal Grant Award Summary The University of Alabama at Birmingham received a $148,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 1, 2025, with a completion date of July 31, 2027. This research project investigates the role of calcium ions (Ca2+) in the assembly of the exosporium of Bacillus anthracis, the bacterium responsible for anthrax. The research focuses on...
- The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $1,173,450 on September 18, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the structure-function relationships of influenza non-structural protein 1 (NS1) and nuclear export protein (NEP) that govern the influenza virus lifecycle. The research will define mechanistic and structural understanding of how NS1 and NEP accomplish their viral...
The National Institute of Allergy and Infectious Diseases awarded the University of Alabama at Birmingham $480,853 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R01AI195802) to investigate the stability and dynamics of the human anti-carbohydrate antibody repertoire across the lifespan. The research examines how chronic exposure to commensal microbiota-derived glycan determinants shapes the anti-carbohydrate (AC) B cell repertoire. Unlike antigens encountered intermittently throughout life, carbohydrate determinants from the microbiota are never cleared and remain continuously available for immune activation. The study tests the hypothesis that recurrent selection driven by this chronic antigen exposure promotes expansion of only a few B cell clones, potentially causing oligoclonal reduction in the AC-reactive antibody repertoire—a pattern observed in older adults but not yet mechanistically understood. The research addresses how somatic hypermutation, germinal center selection, affinity maturation, and B cell differentiation shape antibody responses to carbohydrate structures, and how these processes change with age. Performance occurs in Birmingham, Alabama. The award period runs from August 1, 2026, through July 31, 2031. The assistance type is a Project Grant, which supports competitive research applications reviewed for scientific merit and technical adequacy by peer review and the National Advisory Allergy and Infectious Diseases Council.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $480.9k | 7/30/26 |