The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $769,414 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Iowa. The grant, awarded on July 9, 2025, will support research investigating how the cellular protein SAMHD1 regulates innate immune responses and HIV-1 gene expression in macrophages. The research aims to define the mechanisms by which SAMHD1 suppresses type I interferon induction and NF-kB activation...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant valued at $718,758 to the Texas Biomedical Research Institute under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant is focused on evaluating the use of IL-21-IgFc fusion protein as a host-directed immunotherapy to improve immune reconstitution and reduce the risk of latent tuberculosis (TB) reactivation in Mycobacterium tuberculosis (MTB) and simian immunodeficiency virus (SIV)...
This Project Grant award, totaling $902,964.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research to evaluate mechanisms that restrain or enhance alveolar macrophage (AM) responses to Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, with the goal of understanding the regulation of early events during MTB infection. The key...
The University of Chicago was awarded a $451,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to determine whether a B cell-infecting retrovirus, such as the mouse mammary tumor virus (MMTV), impedes the downregulation of the negative immune regulator DO in germinal center B cells. This aims to prevent the development of virus-specific antibody...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $149,041 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Southern Mississippi. The grant supports the development of novel assays to differentiate and measure the secretion of membrane-bound and soluble forms of tumor necrosis factor (TNF), which play distinct roles in inflammatory and autoimmune diseases. The objectives are to establish a fluorescence-based...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $831,755 over 5 years to New York University (NYU) to conduct research on the role of lung-resident macrophage subsets in regulating type 2 immune responses and trained immunity. The research aims to elucidate the distinct functions of different macrophage populations, particularly nerve- and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,205,213 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The grant, titled "Deciphering Immunopathogenesis of Mucormycosis to Advance Risk Stratification, Diagnosis and Management of the Disease", aims to improve understanding of the immune response and pathogenesis of mucormycosis, a...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $150,921 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia (UVA) to investigate the interplay between membrane rafts and biomolecular condensates in regulating T cell activation. The goal is to provide evidence and mechanistic insights on how these two cellular structures mutually regulate to tune T cell signaling, which can...
This federal Project Grant award, valued at $472,210.00 and effective June 23, 2025 through May 31, 2027, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research by the University of Massachusetts Medical School to investigate the spatiotemporal relationship between CD4+ T resident memory cells and neutrophil recruitment in the lungs during pneumonia in experienced...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $501,011.00 to the University of North Carolina at Chapel Hill to conduct research on biodegradable polymeric microparticles comprised of acetalated dextran and their ability to induce immune tolerance. The goal is to develop an antigen-specific tolerance therapy for autoimmune diseases, an alternative to general...