Project Grant R01AI195533
- The National Institute of Allergy and Infectious Diseases awarded Emory University $3,094,830 under Project Grant R01AI201564 on September 1, 2026, to investigate reassortment of highly pathogenic avian influenza viruses and its effects on viral fitness and host range adaptation. The award funds research examining how H5N1 clade 2.3.4.4B viruses exchange genetic segments with low-pathogenicity avian influenza viruses and human-adapted influenza viruses, with particular focus on assessing...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the Department of Health and Human Services National Institutes of Health, awarded $149,190 to the University of Massachusetts Medical School on December 17, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a project grant (F31AI191745) to investigate hemagglutinin-mediated molecular mechanisms of avian influenza A virus host tropism. The research examines how the hemagglutinin (HA)...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of the University of Pennsylvania $3.16 million on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate immune imprinting and cross-reactive antibody responses to pandemic influenza viruses. The research examines how childhood exposure to seasonal influenza viruses creates long-lived immunological imprints that may provide protection against novel pandemic...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded The Washington University $765,798 on September 3, 2026, to develop a mucosal H5 influenza virus vaccine under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will develop a single-dose mucosal vaccine using a chimpanzee adenovirus vectored platform to confer robust protection against high-dose H5N1 challenge and transmission in pre-clinical...
- The National Institute of Allergy and Infectious Diseases awarded Thomas Jefferson University $221,250 on June 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and evaluate a rabies-vectored vaccine against highly pathogenic avian influenza H5N1. The research will compare hemagglutinin and neuraminidase-based rabies-vectored vaccines expressing H5 antigens of clade 2.3.4.4B with and without an adjuvant (SEPIVAC SWE) in mouse challenge models using...
- The National Institute of Allergy and Infectious Diseases awarded the University of Pennsylvania $627,483 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to elucidate how environmental perturbations determine the duration of enteric viral infection. The research applies an animal model of persistent murine astrovirus infection to understand why some individuals develop prolonged viral shedding for viruses typically considered non-persistent. Preliminary...
- The National Institute of Allergy and Infectious Diseases awarded Georgia State University Research Foundation Inc. $434,938 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop nanobodies as therapeutic agents against H5N1 influenza virus. The project develops potent, broadly neutralizing anti-H5N1 nanobodies with high stability and rapid production capability, engineered for efficient aerosol delivery to the lungs. The research targets the...
- This $649,815 project grant award from the U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program will support research to better understand the transmission, infection, and disease mechanisms of novel H5N1 highly pathogenic avian influenza (HPAI) viruses that have devastated the poultry industry since 2021. The award to the Regents of the University of Minnesota will enable comparative studies of three...
- The Department of Agriculture Animal and Plant Health Inspection Service awarded the Regents of the University of Michigan a cooperative agreement totaling $1,096,690 on February 2, 2026, under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025). The award funds a three-year investigation into highly pathogenic avian influenza (HPAI) A H5N1 transmission among wild mammals and the risk of introduction to poultry operations. Work is performed in Michigan counties with...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, Davis $205,956 on August 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate paramyxoviruses circulating in bats in Puerto Rico and assess their spillover risk to humans and livestock. The project will develop pseudotyped viral reagents and stably transfected cell lines to quantify the entry potential of bat-borne paramyxoviruses across receptors for...
The National Institute of Allergy and Infectious Diseases awarded the University of Pennsylvania $662,804 on September 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate H5N1 transmission and spillover risk across North America through three integrated research aims. The funded work addresses ecological and evolutionary factors governing H5N1 dynamics in wild bird populations. Aim 1 comprises the first comprehensive assessment of H5N1 reassortment in North America, interrogating how novel reassortant viruses are generated, selected, and spill over into mammals, with testing whether reassortment is a key determinant of viral fitness and whether particular genetic combinations are prone to mammal infection. Aim 2 measures how transmission intensity varies across host groups and seasons and how this variation relates to spillover, testing whether seasonally-varying transmission intensity in wild birds results in H5N1 risk that varies across time and can predict spillovers into mammals and agriculture. Aim 3 quantifies the impact of animal movement on viral dissemination. The University of Pennsylvania serves as the recipient and performs the work in Philadelphia, Pennsylvania. The award runs through August 31, 2031. This project grant responds to the 2021–present H5N1 panzootic spreading throughout the Americas, which has devastated wildlife and agriculture and caused 70 human infections, with transmission now sustained by wild, migrating birds carrying these viruses endemically.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $662.8k | 9/3/26 |