Project Grant R01AI200072
- The National Institute of Allergy and Infectious Diseases awarded $721,365 to the University of California Irvine on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a single-dose influenza vaccine platform that extends immune response breadth against viral variants. The funded research combines nanoparticles presenting H5 hemagglutinin antigen with thermo-responsive polymer depots that release antigen slowly, extending exposure time to elicit...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the Department of Health and Human Services National Institutes of Health, awarded $149,190 to the University of Massachusetts Medical School on December 17, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a project grant (F31AI191745) to investigate hemagglutinin-mediated molecular mechanisms of avian influenza A virus host tropism. The research examines how the hemagglutinin (HA)...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $3,068,770 on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop neuraminidase-based influenza vaccines with broad protective immunity. The research systematically analyzes the structure-function relationships of neuraminidase monoclonal antibodies, maps the affinity maturation pathways leading to broadly protective antibodies, and engineers a broadly...
- The National Institute of Allergy and Infectious Diseases awarded the Scripps Research Institute $3.679 million on August 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop self-assembling protein nanoparticles presenting stabilized hemagglutinin, neuraminidase, and M2E antigens for universal influenza vaccine development. The research addresses the structural and immunological challenges of creating a vaccine effective against both seasonal and pandemic...
- The National Institute of Allergy and Infectious Diseases awarded Duke University $695,041 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms underlying combination adjuvant-driven improvement of influenza vaccine responses. The research defines the innate immune signatures and adaptive immune responses elicited by existing and novel combination adjuvants as they relate to driving immune responses directed against influenza virus...
- The National Institute of Allergy and Infectious Diseases awarded Georgia State University Research Foundation Inc. $434,938 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop nanobodies as therapeutic agents against H5N1 influenza virus. The project develops potent, broadly neutralizing anti-H5N1 nanobodies with high stability and rapid production capability, engineered for efficient aerosol delivery to the lungs. The research targets the...
- The National Institute of Allergy and Infectious Diseases awarded the University of Maryland, Baltimore $127,932 on March 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate neuraminidase as a target antigen for a universal influenza virus vaccine. The research addresses the gap between current seasonal influenza vaccines, which elicit only strain-specific immunity with variable effectiveness and provide no protection against novel pandemic...
- The National Institute of Allergy and Infectious Diseases awarded Duke University $703,187 on August 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R01AI201207) to advance understanding of antigenically complex hemagglutinin vaccine formulation requirements and mechanisms of protection in universal influenza vaccine development. The research addresses a core limitation of current influenza vaccines: they induce responses primarily against...
- The National Institute of Allergy and Infectious Diseases awarded Emory University $3,094,830 under Project Grant R01AI201564 on September 1, 2026, to investigate reassortment of highly pathogenic avian influenza viruses and its effects on viral fitness and host range adaptation. The award funds research examining how H5N1 clade 2.3.4.4B viruses exchange genetic segments with low-pathogenicity avian influenza viruses and human-adapted influenza viruses, with particular focus on assessing...
- The National Institute of Allergy and Infectious Diseases awarded the Board of Regents of the University of Nebraska $799,792 on April 1, 2026, to develop universal influenza vaccine immunogens under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds development of a novel vaccine that combines the immunodominant HA1 head domains from EPIGRAPH-designed genes with conserved HA2 stalk domains from consensus immunogens. The research integrates five complementary...
The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded The Washington University $765,798 on September 3, 2026, to develop a mucosal H5 influenza virus vaccine under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will develop a single-dose mucosal vaccine using a chimpanzee adenovirus vectored platform to confer robust protection against high-dose H5N1 challenge and transmission in pre-clinical animal models. The work includes univariate regression analysis to identify dominant correlates of immune protection and strategies to overcome immune imprinting and generate de novo antibody responses against HA protein epitopes that elicit potently neutralizing antibodies. The vaccine is intended to protect against H5N1 virus in individuals with prior immunity to seasonal influenza viruses. Performance is located in St. Louis, Missouri, with a period of performance extending from September 3, 2026, through August 31, 2031. This is a Project Grant, the standard assistance type for investigator-initiated research under the NIH R01 mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $765.8k | 9/3/26 |