Project Grant R01AI194935
Award Date 8/8/25
Completion Date 7/31/29
Dollars Obligated $3.4M
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
- This federal Project Grant award of $664,933 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the cellular and molecular mechanisms of IL-17A in the pathogenesis of psoriatic arthritis. The research will utilize a novel animal model to define the early pathogenic pathways driven by IL-17A that contribute to joint and skin inflammation,...
- This Project Grant award of $459,250 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The award will support research at Cedars-Sinai Medical Center in California to study the mechanisms behind the migration of fibroblast-like synoviocytes (FLS) through the blood vessel endothelial cells (EC) in the synovium of rheumatoid arthritis (RA) patients. The research aims to...
- The $735,372 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Program (CFDA 93.846) supports research to identify the key transcription factors and cytokine signals that regulate the expression of inflammatory chemokine receptors on T cells in chronic autoimmune conditions. The goal is to elucidate the dominant pathways controlling coordinated T cell migration to...
- This $558,045 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to investigate how the enzyme protein phosphatase 2A (PP2A) controls the function of T cells and contributes to the development of systemic lupus erythematosus (SLE). The research aims to determine how PP2A regulates metabolic enzymes involved in...
- This Project Grant award of $139,895.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research into the link between inflammatory arthritis and the development of cardiovascular disease. The key objectives are to investigate whether "trained immunity" - the phenomenon where innate immune cells become reprogrammed to respond more efficiently to a...
- The federal Project Grant award titled "Immune Cell Contributions to Inflammatory Arthritis" is funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $735,460 award to Vanderbilt University Medical Center will support research to investigate the roles of B cells and inflammatory cytokines in the pathogenesis of psoriatic arthritis (PSA) using a mouse model...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $170,101 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, for a project titled "Dissecting the Spatial Heterogeneity of Synovial Inflammation in Rheumatoid Arthritis". The project aims to systematically characterize the spatial heterogeneity of synovial inflammation in rheumatoid...
- This federal Project Grant award, valued at $1,901,310.00 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research project aims to investigate how skin inflammation drives the development of psoriatic arthritis, a condition that affects up to one-third of individuals with psoriasis. The project will use a novel mouse model to study the...
- This federal Project Grant award of $528,558.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The goal of the research project is to study the immune system mechanisms underlying treatment resistance and paradoxical inflammatory side effects in patients with atopic dermatitis who receive the antibody therapy dupilumab. The research will...
- This $300,000 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to the University of Rochester. The project aims to "Decipher the Endotypes and Signature of Non-Response in a Humanized Murine Model of PSA" for psoriatic arthritis, a chronic inflammatory disease. The research will (1) identify cellular and molecular signatures across psoriatic arthritis tissue domains, (2) define CD8+ T cell...