Project Grant R01AI194497
- This $894,552 project grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at the University of Nevada, Las Vegas to probe the effect of a high-fat/high-protein diet on Clostridioides difficile infection. Specifically, the researchers will examine how such a diet impacts inflammation, intestinal permeability, and the gut microbiome before and after antibiotic...
- This Project Grant award, valued at $184,651, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The award will support research at Duke University focused on improving the understanding of the progression from Clostridioides difficile (C. difficile) carriage to active infection. Specifically, the research aims to: 1) Identify metagenomic and metabolomic risk factors present...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to study microbial biomarkers that can predict multi-drug resistant organism (MDRO) colonization and infection in solid organ transplant recipients. The $841,520 award to The Trustees of Columbia University in the City of New York will leverage whole-genome sequencing and metagenomic analysis of gut...
- This Project Grant award of $403,750 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to unravel the relationships between gut microbial signatures, blood microbial signatures, and immune responses in sepsis patients. The research will integrate gut microbial community profiling, metabolomics, intestinal permeability measures, and blood microbial signatures with immune phenotypes and clinical...
- The University of Illinois received a $582,350 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on "Microbiota-Mediated Colonization Resistance to Acinetobacter Baumannii." The research aims to identify key gut resident microbes that can synergize with a complex microbiota to prevent colonization by the multidrug-resistant pathogen Acinetobacter...
- This $241,500 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) and dated Aug 21, 2025, supports research conducted by the University of California, Davis to accelerate microbiota recovery and restore colonization resistance against Clostridioides difficile infection. The project aims to: (1) determine whether treatment with the probiotic Anaerostipes caccae can accelerate microbiota recovery after...
- This federal Project Grant award of $195,213 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Davis to investigate the mechanisms by which the gut microbiota, specifically short-chain fatty acids, can inhibit the growth of the enteric pathogen Yersinia enterocolitica. The research aims to elucidate the molecular mechanisms underlying Y. enterocolitica's sensitivity and...
- This $780,162 Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Old Dominion University from August 2022 through July 2026 exploring the role of nutrient and stress sensing in regulating Clostridioides difficile physiology and behavior within the host. The research aims to determine how the stringent response regulates disease-relevant bacterial processes and characterize enzymes that mediate alarmone metabolism...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $521,030.00 to the University of North Carolina at Chapel Hill to conduct research on the role of phenotypic heterogeneity in the fitness of Clostridioides difficile, a leading cause of antibiotic-associated disease. The goal is to define the interplay between stochastic and regulatory mechanisms underlying the...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $136,104 Project Grant to Tufts University School of Medicine. The grant, awarded on October 24, 2025, will support research to investigate the effect of Clostridioides difficile's (C. difficile) spatial distribution and toxin gene expression within the colon on disease severity. The research will utilize fluorescent reporter strains...
This federal Project Grant award, titled "Dietary Fiber-Microbiome Interactions: Elucidating Mechanisms to Suppress Multi-Drug Resistant Organisms in the Human Gut", was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $3,012,181 award to Duke University aims to conduct a longitudinal human study and computational modeling to understand how dietary fiber and the human gut microbiome impact the colonization of multi-drug resistant organisms (MDROs) such as Clostridioides difficile, vancomycin-resistant Enterococci, and carbapenem-resistant Enterobacterales. The project will leverage a novel DNA sequencing methodology to track human diet, combined with high-throughput culturing of human gut communities and germ-free mouse experiments, to elucidate the key dietary factors and microbial species that influence MDRO fitness and colonization in the gut. This research seeks to provide insights that could help suppress the spread of drug-resistant infections.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 9/10/25 |