Project Grant K23AI177941
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $136,104 Project Grant to Tufts University School of Medicine. The grant, awarded on October 24, 2025, will support research to investigate the effect of Clostridioides difficile's (C. difficile) spatial distribution and toxin gene expression within the colon on disease severity. The research will utilize fluorescent reporter strains...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $521,030.00 to the University of North Carolina at Chapel Hill to conduct research on the role of phenotypic heterogeneity in the fitness of Clostridioides difficile, a leading cause of antibiotic-associated disease. The goal is to define the interplay between stochastic and regulatory mechanisms underlying the...
- This $233,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to optimize culture and metagenomic methods to detect multi-strain Clostridioides difficile (C. difficile) colonization and infection. The 2-year project seeks to enhance the recovery of multiple and cryptic C. difficile strains from stool samples by employing a combination of culture conditions. Additionally, the project will...
- This is a $300,892 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The grant supports research by the University of North Carolina at Chapel Hill to identify and annotate Rho, NusA, and NusG dependent transcriptional terminators in Clostridioides difficile. The objective is to determine how these factors regulate the expression of key virulence genes involved in C. difficile...
- This $780,162 Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Old Dominion University from August 2022 through July 2026 exploring the role of nutrient and stress sensing in regulating Clostridioides difficile physiology and behavior within the host. The research aims to determine how the stringent response regulates disease-relevant bacterial processes and characterize enzymes that mediate alarmone metabolism...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $136,050 to Tufts University School of Medicine to conduct research on the mechanisms that control Clostridioides difficile spore germination. The research aims to understand how C. difficile, which lacks traditional germinant receptors found in other spore-forming bacteria, uses two pseudoprotease enzymes, CspA and...
- This Project Grant award of $2,872,722 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the role of penicillin-binding proteins (PBPs) in the Clostridioides difficile life cycle and develop new PBP inhibitors to target C. difficile sporulation. The research aims to enhance the understanding of PBPs across bacterial species and provide new insights into the unique...
- This $661,693 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to define the structure and function of a new family of peptidoglycan crosslinking enzymes in the opportunistic pathogen Clostridioides difficile. The research aims to advance understanding of C. difficile's cell wall composition and enzymes essential for its survival and virulence, with the potential to inform the...
- This $894,552 project grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at the University of Nevada, Las Vegas to probe the effect of a high-fat/high-protein diet on Clostridioides difficile infection. Specifically, the researchers will examine how such a diet impacts inflammation, intestinal permeability, and the gut microbiome before and after antibiotic...
- This $241,500 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) and dated Aug 21, 2025, supports research conducted by the University of California, Davis to accelerate microbiota recovery and restore colonization resistance against Clostridioides difficile infection. The project aims to: (1) determine whether treatment with the probiotic Anaerostipes caccae can accelerate microbiota recovery after...
This Project Grant award, valued at $184,651, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The award will support research at Duke University focused on improving the understanding of the progression from Clostridioides difficile (C. difficile) carriage to active infection. Specifically, the research aims to: 1) Identify metagenomic and metabolomic risk factors present during C. difficile carriage that are associated with later progression to disease; 2) Assess temporal changes in the metagenome and metabolome linked to progression from carriage to disease; and 3) Identify C. difficile strain attributes, particularly related to toxin regulation, that are associated with risk of progression from carriage to disease. The award period runs from August 8, 2025 to July 31, 2030. Improved understanding of the factors preventing or promoting C. difficile disease progression could inform novel prevention strategies and better direct therapies to high-risk individuals.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $184.7k | 8/8/25 |