Project Grant R01AI193792
- Federal Project Grant Award Summary Cedars-Sinai Medical Center received a $459,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), with an award date of June 20, 2025 and a completion date of May 31, 2027. The research initiative, titled "Synoviocyte Endothelial Cell Cross Talk in Rheumatoid Arthritis," investigates the mechanisms underlying fibroblast-like...
- Federal Project Grant Award Summary Cedars-Sinai Medical Center received a $879,906 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 20, 2025, with completion scheduled for May 31, 2027. This research project investigates the role of High Mobility Group Box 1 (HMGB1), a pro-inflammatory mediator, in the pathogenesis of Kawasaki Disease (KD) vasculitis using a...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $794,183 Project Grant to the Beckman Research Institute of the City of Hope for research investigating the role and regulation of methylarginine effector TDRD3 (Tudor domain-containing protein 3) in T cell immunity. The award, issued April 8, 2026, with a completion date of March 31, 2031, is funded under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $464,750 to Icahn School of Medicine at Mount Sinai on July 7, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project completion period extending through June 30, 2027. The award supports research focused on understanding and modulating T cell plasticity, specifically the transdifferentiation of TH17 cells into regulatory T cells...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Columbia University's Health Sciences Division a Project Grant totaling $452,375 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period from February 13, 2026, through January 31, 2028. This research initiative focuses on investigating the role of tissue-resident T cells in osteoarthritis (OA) and their contribution to inflammatory arthritis development...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3.1 million Project Grant to the University of California, Los Angeles under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 16, 2025, with a completion date of June 30, 2029. This award funds research to evaluate the mechanisms underlying immunosuppression induction and maintenance impacts on T cell function following kidney transplantation. The research employs...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Beckman Research Institute of the City of Hope a Project Grant of $888,941 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for research investigating regulatory T cell (Treg)-mediated thymic regeneration following hematopoietic cell transplantation. The award, effective June 2, 2026, with a completion date of May 31, 2031, funds preclinical research aimed at...
- Federal Project Grant Award Summary The University of Southern California received a $166,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 5, 2025, with completion scheduled for May 31, 2027. This grant supports the development of novel tools for precision targeting of pro-autoimmune Th17 cells to address autoimmune diseases affecting over 23 million Americans. The...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Benaroya Research Institute at Virginia Mason a $267,000 Project Grant on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a 24-month research investigation concluding May 31, 2028. The research deliverables encompass a comprehensive immunological characterization study examining how the therapeutic monoclonal antibody risankizumab...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Feinstein Institutes for Medical Research a $460,625 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 10, 2026, with a completion date of January 31, 2028. This award supports investigator-initiated biomedical research focused on understanding the maturation and maintenance of the germinal center niche, specifically examining follicular...
This $740,319 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports biomedical research conducted by Cedars-Sinai Medical Center in West Hollywood, California. The award, issued June 10, 2026, with completion scheduled for May 31, 2031, funds investigator-initiated research examining the plasticity and conversion of T helper 17 (TH17) cells into pathogenic IL17A-negative cell populations (exTH17) in the context of rheumatoid arthritis (RA). The research delivers scientific knowledge and methodological advances addressing how TH17 cells lose IL17A expression and convert into exTH17 cells that perpetuate joint inflammation despite current IL-17A-targeted therapies. The project produces research findings through three primary investigative aims: characterization of intrinsic and extrinsic mechanisms driving TH17-exTH17 conversion; elucidation of exTH17-mediated joint inflammation; and exploration of exTH17's potential role in RA-associated interstitial lung disease. By leveraging a novel fate-mapping mouse model of autoimmune arthritis, the research is intended to generate translational knowledge enabling development of stage-specific and personalized therapeutic approaches to rheumatoid arthritis that minimize non-specific immunosuppression, thereby advancing understanding of disease mechanisms and improving treatment outcomes for affected patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $740.3k | 6/11/26 |