Project Grant R01AI187989

Award Date 7/16/25
Completion Date 6/30/29
Dollars Obligated $3.1M
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90095, USA
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This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $766,265 to the University of Chicago to conduct research on the role of regulatory T cells (Tregs) in establishing and maintaining transplantation tolerance. The research aims to elucidate the mechanisms by which Tregs program alloreactive T cell anergy during the induction phase of tolerance, as well as the mechanisms by which the elimination...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports innovative research to enhance regulatory immune cell function and extend kidney allograft survival in non-human primates. The $1,455,073 award to the University of Pittsburgh aims to develop new agents and technologies that selectively promote dendritic cell tolerogenicity and regulatory T cell function, with the goal...
This Project Grant award for $327,500 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to better understand the role of the CD43 receptor on effector CD8+ T cells during acute allograft rejection. The key objectives are to: Define the effector mechanisms that distinguish CD43+ effector T cells from CD43- effector T cells, including their differentiation pathways, trafficking...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $210,867 to Drexel University to develop a cell-based therapy for generating donor-specific immune tolerance in kidney transplant recipients. The key products and services being delivered through this award include: Developing "push/pull particle" tolerogenic dendritic cells (PPP-TolDCs) that can be...
This $606,609 Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of California, San Diego (UCSD) to develop T cell alloreactivity and organ transplant risk stratification models using high-resolution HLA and genomic data. The research aims to advance understanding of immune system responses and improve clinical outcomes for organ transplant recipients. The 5-year...
This federal Project Grant award of $1,310,631.89, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports the development and optimization of antibody-targeted nanoparticle delivery systems to selectively target endothelial cells in human organ allografts. The goal is to prevent the expression of surface proteins that contribute to T cell-mediated rejection and improve long-term graft outcomes, thereby reducing the...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to evaluate the use of serum microRNA (miRNA) profiling to assist in the safe tapering of immunosuppression for liver transplant recipients. The $264,596 award will support a 3-phase study design to establish trial procedures, develop the protocol, and assess outcome measures. The research team, led by The...
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This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $196,992 to the University of California, Los Angeles (UCLA) to conduct research on developing regulatory T cells (Tregs) from induced pluripotent stem cells (iPSCs) for potential treatment of autoimmune diseases. The key objectives are to study the role of the transcription factor FOXP3 in Treg development from iPSCs, link exogenous FOXP3...
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The key objectives are to analyze the epigenetic and transcriptional changes induced by ATG compared to non-ATG induction, and determine how these alterations impact T cell phenotype, function, and T cell receptor repertoire. The research aims to provide a comprehensive understanding of how immunosuppression regimens affect the regulation of T cell function, a critical component of the immune system in controlling post-transplant infections. The findings can potentially guide improvements in immunosuppression management and patient outcomes after kidney transplantation.

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