Project Grant R01AI193513
- Federal Grant Award Summary St. Jude Children's Research Hospital Inc. received a $151,040 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), with an award date of March 1, 2026, and a completion date of October 31, 2028. The grant supports research into polymicrobial nasal colonization strategies and consequences, with the research to be conducted at the institution's Memphis, Tennessee...
- Federal Project Grant Award Summary St. Jude Children's Research Hospital Inc. received a $880,417 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 13, 2026, through January 31, 2031. The award supports investigator-initiated biomedical research focused on defining regulatory T cell (Treg) repertoire sustainability and dynamics. The research project will...
- Federal Grant Award Summary St. Jude Children's Research Hospital Inc. received a $508,750 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 13, 2026, with a completion date of January 31, 2028. The award supports research to develop a novel method for engineering high-fidelity regulatory T cells (Tregs) that maintain robust lineage stability and regulatory function for...
- Federal Grant Award Summary St. Jude Children's Research Hospital Inc. received a $3.43 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 22, 2025, through June 30, 2029. The award supports fundamental biomedical research investigating epigenetic checkpoint regulation of naive T-cell quiescence and peripheral tolerance—specifically examining how the ascorbate transporter...
- Federal Project Grant Award Summary St. Jude Children's Research Hospital Inc. received a $148,880 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective November 1, 2025, with a completion date of June 30, 2027. The award funds research aimed at defining the mechanistic drivers of impaired B cell response to Influenza A Virus (IAV) vaccine under conditions of obesity. This...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a $800,557 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective February 19, 2026, with a completion date of January 31, 2031. This investigator-initiated research project is designed to identify and characterize the mechanisms by which Staphylococcus aureus, a gram-positive bacterial pathogen, manipulates inflammasome...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Children's Hospital of Philadelphia $881,303 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 17, 2025, for a project extending through June 30, 2030. This Project Grant funds a comprehensive research initiative utilizing whole genome sequencing (WGS) and diagnostic allele (DA) surveillance to track pathogen transmission and infection dynamics in neonatal...
- Federal Grant Award Summary Seattle Children's Research Institute received a $3.61 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 14, 2025, with a completion date of June 30, 2029. This research project investigates hyaluronidase (HylB), a virulence factor produced by Group B Streptococci (GBS), to elucidate mechanisms by which the enzyme suppresses immune...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a Project Grant of $444,125 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 8, 2025, with a completion date of July 31, 2027. This research project will characterize a previously unknown intercellular signaling pathway in Group B Streptococcus (GBS) and determine its contribution to bacterial pathogenesis. Specifically,...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital $151,040 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on December 4, 2025, to support a project extending through July 31, 2028. This Project Grant funds basic science research investigating the regulatory mechanisms of a small regulatory RNA (sRNA) designated BECO in Pseudomonas aeruginosa, a gram-negative bacterium that causes serious...
St. Jude Children's Research Hospital Inc. received a $867,054 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 15, 2026 through April 30, 2031. The award funds mechanistic research to understand how serotype 3 Streptococcus pneumoniae evades vaccine-induced immunity, with particular focus on the role of the bacterial capsular polysaccharide (CPS) in resisting antibody opsonization and phagocytic killing. The research leverages a murine infection model to define the bacterial and host factors underlying pneumococcal breakthrough infections, which currently account for the majority of vaccine-preventable pneumococcal disease cases despite inclusion in multiple licensed vaccines. The primary deliverables include mechanistic characterization of vaccine-escape mechanisms in serotype 3 pneumococcal isolates and development of tailored protein-based vaccine candidates designed to prevent breakthrough infections. Additionally, the project will generate mechanistic mathematical models predictive of vaccine breakthrough probability and efficacy across bacterially and immunologically diverse populations. These modeling and design outputs are intended to inform improved vaccine development strategies and provide scientific evidence to support enhanced pneumococcal vaccine formulations for both pediatric and adult populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $867.1k | 5/19/26 |