This federal Project Grant award of $440,000 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research at the University of Texas Medical Branch at Galveston (UTMB) to characterize the role of TRIM proteins in the host innate antiviral immunity against vector-borne bunyavirus infections. The project aims to (1) identify TRIM proteins that regulate bunyavirus infection and (2) define...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $254,250 to New York University (NYU) from July 1, 2025 to June 30, 2027. The funding supports research to understand how pathogenic alphaviruses, such as chikungunya virus, infect and spread through human microvascular endothelial cells. The research aims to identify viral and host factors that restrict alphavirus...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports a $453,429 research project on the "Regulation of RNA Editing in Two Life Cycle Stages of Trypanosoma brucei". The 5-year project aims to investigate the key proteins and mechanisms involved in differential RNA editing across the life cycle of this pathogenic kinetoplastid protozoan, which alternates between mammalian...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $185,280 to Texas A&M University System Health Science Center to investigate how the Mycobacterium tuberculosis (MTB) secreted protein Rv1075c interacts with host histone methyltransferases to promote MTB infection. The key objectives are to define changes in histone methylation at innate immune genes during MTB...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $242,185 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M Agrilife Research. The grant supports research to investigate the role of RNA structure in regulating developmental RNA editing in pathogenic trypanosomes, such as Trypanosoma brucei. The key objectives are to: 1) Develop a new technique to assess RNA structure under native cellular conditions versus in vitro,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $226,980.00 to the University of Texas Health Science Center at Houston to conduct research on the role of ethanolamine (EA) utilization in promoting the intracellular replication of the human pathogen Listeria monocytogenes. The research aims to elucidate the key genetic components required for EA metabolism within the intracellular...
The University of Texas Medical Branch at Galveston (UTMB) was awarded a $440,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant, awarded on July 3, 2025 with a completion date of June 30, 2027, will support research to determine the function and mechanism of the long non-coding RNA CHAST in Trypanosoma cruzi infection and dissemination, which causes Chagas...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $408,865 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Vermont & State Agricultural College. The grant supports the development of new tools to study how the protozoan parasite Toxoplasma gondii delivers its "rhoptry effector" proteins into host cells during the invasion process. The goals are to: 1) Develop an assay to test whether the rhoptry...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $431,004 to the University of California, Davis to investigate the fundamental mechanisms underlying the process of "trogocytosis" between the pathogenic amoeba Entamoeba histolytica and human cells. The research aims to elucidate the dynamic interplay between the amoeba and human cells during this...
This federal Project Grant award of $576,501 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by the University of Texas Medical Branch at Galveston (UTMB) on the role of the Lassa virus (LASV) NP exoribonuclease in controlling viral RNA fidelity and replication. The research aims to leverage animal models to investigate the impact of NP exonuclease function on LASV RNA mutation,...