This federal Project Grant award of $696,544 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of California, Davis to uncover the contractile attachment mechanisms of the ventral disc in the intestinal parasite Giardia lamblia. The research aims to leverage new CRISPR-based genetic tools, live imaging, and biophysical assays to evaluate how specific structural...
This $477,226 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to discover novel antiviral systems in microbial eukaryotes. The research will focus on understanding how the amoeba genus Acanthamoeba defends against giant viruses called Megavirales, and then expand that knowledge to other microbial eukaryotes. The project will leverage cutting-edge AI techniques and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $408,865 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Vermont & State Agricultural College. The grant supports the development of new tools to study how the protozoan parasite Toxoplasma gondii delivers its "rhoptry effector" proteins into host cells during the invasion process. The goals are to: 1) Develop an assay to test whether the rhoptry...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $444,688 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Cincinnati. The grant supports a 2-year research project to characterize cyclic AMP (cAMP) signaling microdomains in the protozoan parasite Trypanosoma cruzi, which causes Chagas disease. The research aims to elucidate the specific roles of cAMP signaling in cellular adhesion, metacyclogenesis, and osmotic...
This $435,875 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of California, Merced to interrogate the role of the transcriptional regulator NFKBID in humoral immunity against the parasite Toxoplasma gondii. The research aims to define how NFKBID-deficient T follicular helper cells impact B cell antibody responses, and examine the contribution of NFKBID-dependent...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,194,992 to the University of California, San Diego (UC San Diego) to conduct research on the roles and regulation of tissue-resident CD8 T cells during a persistent viral infection. The key objectives are to: (1) evaluate the role of tissue-resident CD8 T cells in intestinal hyper-permeability and colitis during a sustained viral...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $227,018 to the University of California, Irvine (UCI) from May 1, 2025 to April 30, 2027. The funding supports research to determine the role of microglia, brain-resident immune cells, in defending against Toxoplasma gondii infection in the context of HIV/AIDS-associated immune deficiency. The key objectives...
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 - Allergy and Infectious Diseases Research, will support research to investigate the genetic mechanisms that determine host susceptibility to low virulence strains of the Toxoplasma gondii parasite in mice. The $269,054 award, effective November 8, 2024 through October 31, 2026, will enable researchers at the University of California, Merced to leverage the...
This Project Grant award, valued at $218,767.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The grant supports a research project at the University of Washington to build a single-cell transcriptional atlas of the protozoan parasite Giardia during its encystation process - the differentiation into dormant, encapsulated cell types. The goals are to characterize gene...