Project Grant R01AI192943

Award Date 8/1/25
Completion Date 7/31/30
Dollars Obligated $383K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Louisiana, USA
Similar Awards
This federal Project Grant award, with ID R01AI189439, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $382,500 grant supports research at Tulane University to investigate the role of Taxilin Alpha (TXLNA) in regulating the cGAS-STING signaling pathway, which is involved in the innate immune response to cytosolic DNA. The research aims to determine how TXLNA mediates the activation...
This Project Grant award, valued at $162,000.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The primary objectives are to uncover novel biology at the interface of cell death modalities, identify mechanisms through which the LRRK2 gene regulates and promotes cell death and inflammation, and map inflammatory phenotypes to connect in vitro biology with disease in vivo. The...
This federal Project Grant award for $246,623.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at New York University School of Medicine to study the molecular control of tolerogenic dendritic cell function. The research aims to characterize the dendritic cell subset responsible for maintaining T cell tolerance, including investigating aberrant cytokine...
This federal Project Grant award of $3,768,791.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research focused on understanding the mechanisms of herpesvirus nuclear egress. The principal investigator at Tufts University School of Medicine will conduct structural and functional studies on the nuclear egress complex (NEC) across different herpesvirus subfamilies, visualize the nuclear...
This Project Grant award, valued at $735,078, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The funding supports a 5-year research project to investigate the molecular mechanisms of innate immune memory in humans, with a focus on understanding the epigenetic determinants that enable long-lasting "trained immunity" in myeloid and lymphoid progenitor cells. The...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $130,932 to Harvard Medical School to elucidate the molecular mechanisms underlying the activation and regulation of the inflammasome executioner protein Gasdermin D (GSDMD). The research aims to interrogate this complex system through a combination of biochemistry, biophysics, and cell biology, with the goal...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $971,109 over approximately 3 years starting June 2025 to researchers at the University of California, Merced. The project will study the binding dynamics and oligomerization of DNA sensor proteins AIM2 and IFI16, which are involved in pathogen detection and inflammatory signaling. Using advanced microscopy techniques,...
This federal Project Grant award of $658,657, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at the University of Virginia on the biophysical and functional coupling of protein condensates to ordered lipid domains in T-cells. The research aims to reveal the mechanisms by which protein condensates and membrane domains cooperatively regulate T-cell signal transduction and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $578,093 to the University of Massachusetts Medical School to conduct research on a novel human damage-associated molecular pattern (DAMP) receptor, its murine counterpart, and their ligand, GAPDH. The research aims to elucidate the structure, function, and pathophysiology of this DAMP receptor system in both humans...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $518,400 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The New York Structural Biology Center, Inc. (NYSBC), a non-profit research organization. The funding will support a 2-year project to determine the three-dimensional structure of a divergent, bipartite internal ribosome entry site (IRES) from the Giardia lamblia virus. This IRES element is unique in that it...

This federal Project Grant award of $382,500.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tulane University. The funding supports a 5-year research project to investigate the role of nuclear cyclic GMP-AMP synthase (cGAS) in the DNA sensing signaling pathway and elucidate the regulatory mechanisms of nuclear cGAS. The research aims to determine the mechanisms controlling cGAS nuclear localization and activation, the mechanisms by which nuclear cGAS senses DNA viruses, and the mechanisms controlling nuclear cGAS activation upon DNA damage. If successful, this research could lead to new strategies to intervene in cGAS signaling to modulate innate immune responses in infectious diseases, autoimmune disorders, and cancers.

Generated 8/5/25, 3:08 AM