Project Grant K22AI174008

Award Date 5/2/25
Completion Date 4/30/27
Dollars Obligated $162K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Texas, USA
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  1. Identify the kinase-dependent interactions between LRRK2 and its substrates during programmed cell death pathways like pyroptosis and necroptosis in macrophages.
  2. Observe which cell populations undergo necroptosis and determine the key drivers of the observed hyperinflammatory response in vivo using LRRK2 mouse models.

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