Project Grant R01AI190922
- Federal Grant Award Summary Yale University received a $837,497 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 6, 2025, through April 30, 2030. The grant funds basic science research focused on elucidating the molecular mechanisms by which phosphoinositide 3-kinase gamma (PI3KG) orchestrates antibody responses in B cells. The research deliverables encompass three...
- Federal Project Grant Award Summary Yale University received a $2,685,326 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded July 7, 2025, with a completion date of June 30, 2029. The award supports biomedical research investigating the regulation of neutrophil plasticity, heterogeneity, and functional ambivalency by Wnt5 proteins in the context of colitis. The research focuses on...
- Federal Grant Award Summary Yale University received a $778,828 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 6, 2026 through March 31, 2031. The award supports biomedical research investigating novel loss-of-function gene variants in ZFYVE21 and their role in dysregulated innate immunity. The project delivers integrated research products through a...
- Federal Grant Award Summary Yale University received a $3.13 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 25, 2025, with a completion date of June 30, 2029. The grant funds investigator-initiated biomedical research focused on elucidating the mechanisms of lymphoid-specific beta-catenin protein degradation in B-lymphoid cells. The research will characterize how B-cells...
- Federal Grant Award Summary Yale University received a $792,513 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 8, 2026, with a completion date of March 31, 2031. The project, "Serotype Re-emergence and Vaccine Impact in the Era of Next-Generation Pneumococcal Vaccines," will deliver mathematical and statistical modeling analyses to understand the...
- Federal Grant Award Summary Yale University has received a $251,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 2, 2025, with completion targeted for August 31, 2027. The award supports research to identify new antigens responsible for seronegative myasthenia gravis (SNMG), an autoimmune neuromuscular disorder affecting patients who lack detectable autoantibodies...
- Federal Grant Award Summary Yale University received a $453,629 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 8, 2025, with completion targeted for June 30, 2027. The grant supports development and application of PHAGE-SEQ, a high-throughput technology combining phage display of nanobodies (VHH recognition domains derived from camelid heavy chain-only immunoglobulins)...
- Federal Grant Award Summary Yale University received a $4.9 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 14, 2025, with a completion date of June 30, 2029. The grant supports biomedical research investigating the mechanistic pathways by which gut microbiota and white adipose tissue control the CD4 T-cell compartment and facilitate T-cell migration from the...
- Federal Grant Award Summary Yale University received a $2,543,522 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 3, 2025, with completion targeted for August 31, 2029. The award funds investigator-initiated biomedical research examining novel mechanisms of protein homeostasis mediated by the molecular chaperone DnaK in bacterial cells. This research addresses...
- Federal Grant Award Summary Yale University received a $662,465 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 6, 2026, with a completion date of January 31, 2031. The grant funds research into developing durable and broadly protective respiratory mucosal immunity against zoonotic coronaviruses through next-generation intranasal booster vaccines. The research addresses...
Yale University received a $735,631 Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 1, 2026, through March 31, 2031. The award funds basic immunological research investigating the origin, function, and biological properties of a novel population of CX3CR1+ neutrophils—specialized white blood cells distinct from canonical neutrophils. The research involves developing comprehensive transcriptional maps of the full neutrophil compartment in mice and humans, utilizing computational modeling and fate mapping studies to characterize the myeloid progenitors that produce these cells and the cytokines controlling their production. The deliverables under this award include detailed characterization of CX3CR1+ neutrophil phenotypes, tissue distribution, and lifespan compared with conventional neutrophils, as well as assessment of their capacity to function as antigen-presenting cells and immunosuppressive agents. The research will examine these neutrophils in the context of lung cancer and vaccinia infection models to determine their role in modulating adaptive immune responses and their potential therapeutic applications. This fundamental research contributes to understanding neutrophil heterogeneity and may inform future strategies to therapeutically manipulate different granulopoietic pathways for antimicrobial, inflammatory, or tissue-reparative purposes.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $735.6k | 3/30/26 |