Project Grant R01AI190001

Award Date 7/21/25
Completion Date 6/30/30
Dollars Obligated $589K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92093, USA
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The key focus areas include:

  1. Evaluating conditional and sex-specific lethal systems that can restrict lethal transgene expression to reduce fitness load on the mosquito population. This includes temperature-inducible and transactivating systems that can confine female-lethal effectors in space and time.
  2. Developing a toxin-antidote "Home-and-Rescue" gene drive to reduce the accumulation of resistant alleles and improve overall drive performance in Aedes aegypti, which has inherently low homing efficiencies.
  3. Studying the population dynamics of these sex-specific and conditional-lethal gene drives to better predict their performance and safety considerations in wild mosquito populations.

This 5-year project, awarded on July 21, 2025, will be carried out by researchers at the University of California, San Diego.

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