This Project Grant award, totaling $764,591, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to study the differential regulation of cell cycle entry and apoptosis in cytolytic lymphocytes, particularly natural killer (NK) cells, with a focus on understanding how genetic variants affecting DNA replication (the "replisome") can impair NK cell function. The research will use biochemical, single-molecule imaging, and genetic/epigenetic approaches to define how replisome protein function and cell cycle progression are regulated in lymphoid progenitors and mature cells. It will also identify lineage-specific sensors that control survival or apoptosis decisions in response to replication stress, with the goal of developing strategies to rescue NK cell deficiencies. The award was granted to The Trustees of Columbia University in the City of New York, which has significant expertise in biomedical research, public health, and federal grant program management.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $764.6k | 7/23/25 |